Methylisothiazolinone hydrochloride

Cat. No.: HY-W010243 Purity: 99.40%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Methylisothiazolinone hydrochloride is the constituent of the biocide Kathon CG. Methylisothiazolinone hydrochloride is an isothiazolone derivative widely used as a preservative. Methylisothiazolinone hydrochloride is also a moderate sensitizer and reacts with GSH.

For research use only. We do not sell to patients.

Methylisothiazolinone hydrochloride Chemical Structure

CAS No. : 26172-54-3

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g	USD 90	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Methylisothiazolinone hydrochloride:

Methylisothiazolinone-d₃ hydrochloride In-stock
Methylisothiazolinone In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

151.61

Formula

C₄H₆ClNOS

CAS No.

26172-54-3

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C)SC=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (659.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5959 mL	32.9794 mL	65.9587 mL
5 mM	1.3192 mL	6.5959 mL	13.1917 mL
10 mM	0.6596 mL	3.2979 mL	6.5959 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.40%

Select Batch:

Data Sheet (276 KB) SDS (786 KB)

COA (255 KB) HNMR (115 KB) RP-HPLC (196 KB)

Handling Instructions (2659 KB)

References

[1]. Rubén Alvarez-Sánchez, et al. Covalent Binding of the 13C-labeled Skin Sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a Model Peptide and Glutathione. Bioorg Med Chem Lett. 2004 Jan 19;14(2):365-8. [Content Brief]

[2]. Aynur O Aptula, et al. From Experiment to Theory: Molecular Orbital Parameters to Interpret the Skin Sensitization Potential of 5-chloro-2-methylisothiazol-3-one and 2-methylisothiazol-3-one. Chem Res Toxicol. 2005 Feb;18(2):324-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.5959 mL	32.9794 mL	65.9587 mL	164.8968 mL
	5 mM	1.3192 mL	6.5959 mL	13.1917 mL	32.9794 mL
	10 mM	0.6596 mL	3.2979 mL	6.5959 mL	16.4897 mL
	15 mM	0.4397 mL	2.1986 mL	4.3972 mL	10.9931 mL
	20 mM	0.3298 mL	1.6490 mL	3.2979 mL	8.2448 mL
	25 mM	0.2638 mL	1.3192 mL	2.6383 mL	6.5959 mL
	30 mM	0.2199 mL	1.0993 mL	2.1986 mL	5.4966 mL
	40 mM	0.1649 mL	0.8245 mL	1.6490 mL	4.1224 mL
	50 mM	0.1319 mL	0.6596 mL	1.3192 mL	3.2979 mL
	60 mM	0.1099 mL	0.5497 mL	1.0993 mL	2.7483 mL
	80 mM	0.0824 mL	0.4122 mL	0.8245 mL	2.0612 mL
	100 mM	0.0660 mL	0.3298 mL	0.6596 mL	1.6490 mL