(E)-Ajoene
Based on 1 Customer Validation
(E)-Ajoene is an organosulfur compound and a neuroprotective agent with oral activity. (E)-Ajoene attenuates ischemia/reperfusion-induced hyperactivity, neuronal death in the hippocampal CA1 region, reactive astrogliosis, and reactive microgliosis. (E)-Ajoene is the E isomer of Ajoene (HY-106784) found in oil-macerated garlic products. (E)-Ajoene can be used for research on transient forebrain ischemia.
For research use only. We do not sell to patients.
- Purity : 95%
- CAS No.: 92284-99-6
- Formula: C9H14OS3
- Molecular Weight:234.40
-
Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
HY-114623
Prostaglandin D2 methyl esterDP Receptor Inhibitor -
HY-N9515
Diallyl tetrasulfideDiallyl Tetrasulfide -
HY-B0220S1
Erythromycin-13C,d3Stable Isotope -
HY-W018386A
3-Bromo-L-tyrosine TFAAmino Acid Derivative -
HY-116920
AlyssinBioactive Isothiocyanate -
HY-105387
HeliquinomycinDNA Helicase Inhibitor -
HY-117872
Sartorypyrone A
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Fibroblast | IC50 |
17.6 μM
Compound: 1
|
Anticancer activity against cobalt radiation CT-1 transformed fibroblasts
Anticancer activity against cobalt radiation CT-1 transformed fibroblasts
|
[PMID: 18774712] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Mongolian gerbils (purchased from Japan SLC Inc.)[2]
-
Dosage:25 mg/kg
-
Administration:p.o.; single dose; 30 min before ischemic surgery
-
Result:Increased locomotor activity by 2.4-fold compared to pre-ischemia levels 1 day after ischemia/reperfusion.
Preserved 18.7% of cresyl violet-positive neurons in the stratum pyramidale of the hippocampal CA1 region relative to the sham control group 5 days after ischemia/reperfusion.
Showed slightly lower GFAP immunoreactivity in CA1 region astrocytes compared to vehicle-treated animals.
Exhibited lower Iba-1 immunoreactivity in activated microglia aggregated in the stratum pyramidale compared to the vehicle-treated group.
Chemical Information
-
CAS No. 92284-99-6
-
Appearance Liquid
-
Molecular Weight 234.40
-
Formula C9H14OS3
-
Color Colorless to light yellow
-
SMILES
O=S(C/C=C/SSCC=C)CC=C
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Solution, -20°C, 2 years
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Rakshit D, et al. The Pharmacological Activity of Garlic (Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential. ACS Chem Neurosci. 2023 Mar 15;14(6):1033-1044. [Content Brief]
[2]. Yoo DY, et al. Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Oct;72:1-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E)-Ajoene Related Classifications
HY-106784A Related Classifications
Powered by Bioz