2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123037R
    Triadimefon (Standard)
    		Inhibitor
    Triadimefon (Standard) is the analytical standard of Triadimefon (HY-123037). This product is intended for research and analytical applications. Triadimefon is an orally active fungicide. Triadimefon significantly reduces the phosphorylation of AKT1 and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory.
    Triadimefon (Standard)
  • HY-N19791
    6-Methoxymellein
    		Inhibitor
    6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44+/CD24− breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot.
    6-Methoxymellein
  • HY-W706180
    (±)-Triadimefon-d4
    		Inhibitor 99.47%
    (±)-Triadimefon-d4 is deuterium labeled Triadimefon. Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.
    (±)-Triadimefon-d<sub>4</sub>
  • HY-118578
    Furalaxyl
    		Inhibitor 99.3%
    Furalaxyl (CGA 38140) is a potent fungicide. Furalaxyl is highly selective to fungi of the order of the Peronosporales.
    Furalaxyl
  • HY-23155R
    2-Phenylethyl isothiocyanate (Standard)
    		Inhibitor
    2-Phenylethyl isothiocyanate (Standard) is the analytical standard of 2-Phenylethyl isothiocyanate. This product is intended for research and analytical applications. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternate might be via reduction in toxin content and breakdown of cell membrane integrity.
    2-Phenylethyl isothiocyanate (Standard)
  • HY-B0847R
    Propiconazole (Standard)
    		Inhibitor
    Propiconazole (Standard) is the analytical standard of Propiconazole. This product is intended for research and analytical applications. Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals.
    Propiconazole (Standard)
  • HY-W160679
    7-(Carboxymethoxy)-4-methylcoumarin
    		Inhibitor 99.61%
    7-(Carboxymethoxy)-4-methylcoumarin (Compound VIIIa) is the antibacterial and antifungal agent that exhibits inhibitory activity against S. aureus, B. cereus, S. lutea, C. albicans, C. glabrata, and C. parapsilosis.
    7-(Carboxymethoxy)-4-methylcoumarin
  • HY-40354AR
    Tofacitinib citrate (Standard)
    		Inhibitor
    Tofacitinib (citrate) (Standard) is the analytical standard of Tofacitinib (citrate). This product is intended for research and analytical applications. Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.
    Tofacitinib citrate (Standard)
  • HY-14283R
    Luliconazole (Standard)
    		Inhibitor
    Luliconazole (Standard) is the analytical standard of Luliconazole. This product is intended for research and analytical applications. Luliconazole (NND 502) is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including dermatophytosis, tinea corporis, tinea pedis et al.
    Luliconazole (Standard)
  • HY-W726127
    Propamocarb hydrochloride
    		Inhibitor 99.26%
    Propamocarb hydrochloride is a systemic fungicide. Propamocarb hydrochloride is widely used to protect cucumbers, tomatoes and other plants from pathogens.
    Propamocarb hydrochloride
  • HY-U00181
    Fludazonium chloride
    		Inhibitor 99.84%
    Fludazonium chloride (R23633) is an anti-fungal agent, which can be used in the treatment and prevention of superficial and systemic fungal infections.
    Fludazonium chloride
  • HY-W414596
    Metconazole
    		Inhibitor
    Metconazole is a 14α-demethylation inhibitor (DMI) fungicide. Metconazole inhibits fungal ergosterol biosynthesis, inhibits mycelial growth and conidial germ tube elongation. Metconazole reduces antioxidant enzyme activities. Metconazole reduces occurrence of Fusarium crown rot in wheat.
    Metconazole
  • HY-B1863
    Iprobenfos
    		Inhibitor 99.87%
    Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity.
    Iprobenfos
  • HY-N11546
    Sapindoside B
    		Inhibitor
    Sapindoside B is a substance with hepatoprotective activity, and also acts as a cytochrome P-450 (cytochrome P-450) inhibitor, antibacterial agent and membrane-disrupting agent. Sapindoside B reversibly inhibits the content of cytochrome P-450 in liver microsomes, suppresses the phenobarbital-induced increase in enzyme content, reduces the production of active metabolites mediated by cytochrome P-450, and alleviates hepatotoxic injury. Sapindoside B binds to Cutibacterium acnes lipase, reduces lipase activity, inhibits biofilm formation, and decreases bacterial adhesion. Sapindoside B exhibits cytotoxicity against human cancer, liver cancer, leukemia and glioblastoma cells. Sapindoside B inhibits mycelial growth of phytopathogenic fungal strains, possesses antibacterial activity against dermatophytes, and also has hemolytic/membrane-lytic activity. Sapindoside B can be used in research related to liver injury, Cutibacterium acnes biofilm-associated infections, gastric cancer, carcinoma, promyelocytic leukemia, glioblastoma, apple scab and grape gray mold.
    Sapindoside B
  • HY-108009
    Rezafungin
    		Inhibitor
    Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp..
    Rezafungin
  • HY-B0101B
    Fluconazole mesylate
    		Inhibitor
    Fluconazole (mesylate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
    Fluconazole mesylate
  • HY-N3544R
    Caryophyllene oxide (Standard)
    		Inhibitor
    Caryophyllene oxide (Standard) ((-)-Caryophyllene oxide (Standard)) is the analytical standard of Caryophyllene oxide (HY-N3544). This product is intended for research and analytical applications. Caryophyllene oxide is a bicyclic sesquiterpene with anticancer effects. Caryophyllene oxide induces apoptosis of PC-3 cells. Caryophyllene oxide shows analgesic and anti-inflammatory activities. Caryophyllene oxide has insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic properties.
    Caryophyllene oxide (Standard)
  • HY-119123
    Voxvoganan
    		Inhibitor
    Voxvoganan (LTX-109), a topical antimicrobial, is highly effective against S. aureus with a MIC range of 2 to 4 μg/mL. Voxvoganan can be used for the research of bacterial skin infections, fungal infections and nasal decolonisation of MRSA.
    Voxvoganan
  • HY-177849
    Liposomal Amphotericin B
    		Inhibitor
    Liposomal Amphotericin B is a liposome-encapsulated form of Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. Amphotericin B binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. Liposomal Amphotericin B can significantly reduce the toxicity of Amphotericin B.
    Liposomal Amphotericin B
  • HY-N8015R
    Octanal (Standard)
    		Inhibitor
    Octanal (Standard) is the analytical standard of Octanal. This product is intended for research and analytical applications. Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC50 value of 3.5 μg/mL.
    Octanal (Standard)
Cat. No. Product Name / Synonyms Application Reactivity