6-Methoxymellein

6-Methoxymellein (0.5-3 mM; 24 h) suppresses proliferation of MDA-MB-231 and MCF-7 human breast cancer cells in a concentration-dependent manner, with significant inhibition starting at 0.8 mM for MDA-MB-231 cells and 0.5 mM for MCF-7 cells after 24-hour incubation^[1].
6-Methoxymellein (0.2-1 mM, 0.5-1 mM; 7-day culture period) inhibits mammosphere formation by MDA-MB-231 and MCF-7 human breast cancer cells, reducing mammosphere size, number, and formation efficiency in a concentration-dependent manner, with maximum inhibition at 1 mM^[1].
6-Methoxymellein (1 mM; 24 h) significantly inhibits migration of MDA-MB-231 and MCF-7 human breast cancer cells^[1].
6-Methoxymellein (0.5-1 mM; 7-day culture period) inhibits colony formation by MDA-MB-231 and MCF-7 human breast cancer cells in a concentration-dependent manner, with maximum inhibition at 1 mM after 7 days of culture^[1].
6-Methoxymellein (1 mM; 24 h) reduces the proportion of CD44⁺/CD24⁻ breast cancer stem-like cells in MDA-MB-231 cultures from 80.3% to 41.6% after 24-hour incubation^[1].
6-Methoxymellein (1 mM; 48 h) reduces protein expression of the stemness markers c-Myc, Sox-2, and Oct4 in MDA-MB-231 human breast cancer cell-derived mammospheres after 2 days of treatment^[1].
6-Methoxymellein (1 mM; 48 h) suppresses nuclear localization of NF-κB p65 and p50 in MDA-MB-231 human breast cancer cell-derived mammospheres after 48-hour incubation, without altering total cellular levels of these subunits^[1].
6-Methoxymellein (1 mM; 1, 2, 3 days post-treatment) inhibits growth of MDA-MB-231 human breast cancer cell-derived mammosphere cells over a 3-day period^[1].
6-Methoxymellein (1 mM) inhibits NF-κB DNA binding activity in nuclear extracts from MDA-MB-231 human breast cancer cell-derived mammospheres^[1].
6-Methoxymellein (1 mM; 48 h) significantly reduces secretion of IL-6 and IL-8 by MDA-MB-231 human breast cancer cell-derived mammospheres after 2 days of treatment^[1].
6-Methoxymellein (1 mM; 48 h) significantly reduces mRNA transcription of IL-6 and IL-8 in MDA-MB-231 human breast cancer cell-derived mammospheres after 2 days of treatment^[1].
6-Methoxymellein (6.25-200 μg/mL) potently inhibits growth of the Trichophyton rubrum T.R.1085 S isolate, with an MIC of 6.25 μg/mL, and produces increasing inhibition zone diameters with increasing concentrations up to 29 mm at 200 μg/mL^[2].
6-Methoxymellein (1.5625-200 μg/mL) dose-dependently inhibits biofilm formation by the Trichophyton rubrum T.R.1085 S isolate, reaching a maximum inhibition of 68.38% at 200 μg/mL^[2].
6-Methoxymellein (6-MM) (>30 μg/g tissue; 1-2 weeks) accumulated in UV-C treated carrot (Daucus carota L.) slices inhibits growth of Botrytis cinerea and Sclerotinia sclerotiorum at cold storage temperatures (1°C, 4°C), with concentrations above 30 μg/g tissue inhibiting B. cinerea and maximum inhibition at ~60 μg/g, leading to up to 88.5% reduction in fungal growth^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.