13410-15-6
Chemical Structure
6-Methoxymellein
- CAS No.: 13410-15-6
- Formula:C11H12O4
- Molecular Weight:208.21
InChIKey: AIFNAMVERSBWPS-ZCFIWIBFSA-N
SMILES: OC1=C2C(C[C@H](OC2=O)C)=CC(OC)=C1
Biological Activity: 6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44+/CD24− breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot[1][2][3].
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6-Methoxymellein | 6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44+/CD24− breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot. | |||||||||||||||||||||
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- [1]. Liu R, et al. 6-Methoxymellein Isolated from Carrot (Daucus carota L.) Targets Breast Cancer Stem Cells by Regulating NF-κB Signaling. Molecules. 2020 Sep 23;25(19):4374. [Content Brief]
- [2]. Ahmed Hagag, et al. Antibiofilm potential of 6-methoxymellein from geranium-associated Aspergillus caespitosus endophyte against clinical isolates of dermatophytes: Phytochemical, in silico and in vitro investigation. South African Journal of Botany 167 (2024) 448-456.
- [3]. J. Mercier, et al. Induction of 6-Methoxymellein and Resistance to Storage Pathogens in Carrot Slices by UV-C. Phytopathology 137, 44-54 (1993).
Keywords
