Histamine Receptor Antagonist

Histamine Receptor Antagonists (119):

Cat. No.	Product Name	Effect	Purity

HY-12532

Astemizole	Antagonist	99.62%
Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM.

HY-B0725

Doxepin Hydrochloride	Antagonist	99.84%
Doxepin hydrochloride is an orally active tricyclic antidepressant agent.

HY-12537

Peptide 401	Antagonist
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

HY-B0781

Promethazine hydrochloride	Antagonist	≥98.0%
Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.

HY-B0286A

Chlorpheniramine maleate	Antagonist	99.90%
Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM.

HY-W010841

Levocetirizine dihydrochloride	Antagonist	99.56%
Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist.

HY-B1281

Mepyramine maleate	Antagonist	99.96%
Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with K_ds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pK_d of 9.4 for H1 receptor.

HY-B0548A

Hydroxyzine dihydrochloride	Antagonist	99.96%
Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist.

HY-B0377

Famotidine	Antagonist	99.35%
Famotidine (MK-208) is a competitive histamine H2-receptor antagonist.

HY-B0281A

Ranitidine hydrochloride	Antagonist	≥98.0%
Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC₅₀ of 3.3 μM that inhibits gastric secretion.

HY-19705B

Adriforant hydrochloride	Antagonist	≥98.0%
Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (K_i=2.4 nM) and is also a functional (K_i=1.56 nM) antagonist.

HY-14537

Latrepirdine dihydrochloride	Antagonist	99.71%
Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors.

HY-12199B

Pitolisant hydrochloride	Antagonist	99.94%
Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (K_i=0.16 nM).

HY-30234A

Clemizole hydrochloride	Antagonist	99.99%
Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication.

HY-B2168

Mequitazine	Antagonist	99.99%
Mequitazine is a potent, and long-acting histamine H₁ antagonist.

HY-B1589A

Carbinoxamine maleate salt	Antagonist	99.81%
Carbinoxamine maleate salt is a histamine H1 receptor antagonist.

HY-B0895

Hydroxyzine pamoate	Antagonist	99.51%
Hydroxyzine pamoate is a histamine H1-receptor antagonist.

HY-14111

GSK189254A	Antagonist	98.09%
GSK189254A (GSK189254) is a novel, potent and selective histamine H3 receptor antagonist with pK_i values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.

HY-B1303A

Mebhydrolin	Antagonist	99.58%
Mebhydrolin is a specific histamine H₁ receptor antagonist.

HY-B0538A

Pemirolast potassium	Antagonist	99.93%
Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

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