1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Histamine Receptor
  4. Histamine Receptor Isoform
  5. Histamine Receptor Antagonist

Histamine Receptor Antagonist

Histamine Receptor Antagonists (119):

Cat. No. Product Name Effect Purity
  • HY-12532
    Antagonist 99.62%
    Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM.
  • HY-B0725
    Doxepin Hydrochloride
    Antagonist 99.84%
    Doxepin hydrochloride is an orally active tricyclic antidepressant agent.
  • HY-12537
    Peptide 401
    Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).
  • HY-B0781
    Promethazine hydrochloride
    Antagonist ≥98.0%
    Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.
  • HY-B0286A
    Chlorpheniramine maleate
    Antagonist 99.90%
    Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM.
  • HY-W010841
    Levocetirizine dihydrochloride
    Antagonist 99.56%
    Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist.
  • HY-B1281
    Mepyramine maleate
    Antagonist 99.96%
    Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.
  • HY-B0548A
    Hydroxyzine dihydrochloride
    Antagonist 99.96%
    Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist.
  • HY-B0377
    Antagonist 99.35%
    Famotidine (MK-208) is a competitive histamine H2-receptor antagonist.
  • HY-B0281A
    Ranitidine hydrochloride
    Antagonist ≥98.0%
    Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion.
  • HY-19705B
    Adriforant hydrochloride
    Antagonist ≥98.0%
    Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (Ki=2.4 nM) and is also a functional (Ki=1.56 nM) antagonist.
  • HY-14537
    Latrepirdine dihydrochloride
    Antagonist 99.71%
    Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors.
  • HY-12199B
    Pitolisant hydrochloride
    Antagonist 99.94%
    Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
  • HY-30234A
    Clemizole hydrochloride
    Antagonist 99.99%
    Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication.
  • HY-B2168
    Antagonist 99.99%
    Mequitazine is a potent, and long-acting histamine H1 antagonist.
  • HY-B1589A
    Carbinoxamine maleate salt
    Antagonist 99.81%
    Carbinoxamine maleate salt is a histamine H1 receptor antagonist.
  • HY-B0895
    Hydroxyzine pamoate
    Antagonist 99.51%
    Hydroxyzine pamoate is a histamine H1-receptor antagonist.
  • HY-14111
    Antagonist 98.09%
    GSK189254A (GSK189254) is a novel, potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.
  • HY-B1303A
    Antagonist 99.58%
    Mebhydrolin is a specific histamine H1 receptor antagonist.
  • HY-B0538A
    Pemirolast potassium
    Antagonist 99.93%
    Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.