1. Signaling Pathways
  2. GPCR/G Protein
    Immunology/Inflammation
    Neuronal Signaling
  3. Histamine Receptor
  4. Histamine Receptor Isoform
  5. Histamine Receptor Antagonist

Histamine Receptor Antagonist

Histamine Receptor Antagonists (113):

Cat. No. Product Name Effect Purity
  • HY-B0377
    Famotidine
    Antagonist 99.68%
    Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
  • HY-B1281
    Mepyramine maleate
    Antagonist 99.93%
    Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.
  • HY-30234S
    Clemizole-d4
    Antagonist 99.82%
    Clemizole-d4 is a deuterium labeled Clemizole. Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication.
  • HY-12537
    Peptide 401
    Antagonist 98.26%
    Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).
  • HY-B0281A
    Ranitidine hydrochloride
    Antagonist 99.88%
    Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9.
  • HY-B0548A
    Hydroxyzine dihydrochloride
    Antagonist 99.81%
    Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder.
  • HY-19705B
    Adriforant hydrochloride
    Antagonist ≥98.0%
    Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (Ki=2.4 nM) and is also a functional (Ki=1.56 nM) antagonist.
  • HY-12199B
    Pitolisant hydrochloride
    Antagonist 99.67%
    Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
  • HY-30234A
    Clemizole hydrochloride
    Antagonist 99.99%
    Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole hydrochloride is an inhibitor of TRPC5 channel. The IC50 of Clemizole hydrochloride for RNA binding by NS4B is 24 nM, whereas its EC50 for viral replication is 8 µM.
  • HY-W010841
    Levocetirizine dihydrochloride
    Antagonist 99.56%
    Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.
  • HY-14111
    GSK189254A
    Antagonist 98.09%
    GSK189254A (GSK189254) is a novel, potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.
  • HY-B0538A
    Pemirolast potassium
    Antagonist 99.93%
    Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.
  • HY-B0895
    Hydroxyzine pamoate
    Antagonist 99.84%
    Hydroxyzine pamoate is a histamine H1-receptor antagonist.
  • HY-14537
    Latrepirdine dihydrochloride
    Antagonist 99.71%
    Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β () secretion.
  • HY-B1589A
    Carbinoxamine maleate salt
    Antagonist 99.81%
    Carbinoxamine maleate salt is a histamine H1 receptor antagonist.
  • HY-I0021
    Bepotastine
    Antagonist 98.03%
    Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research.
  • HY-B1303A
    Mebhydrolin
    Antagonist 99.78%
    Mebhydrolin is a specific histamine H1 receptor antagonist.
  • HY-B0640A
    Epinastine hydrochloride
    Antagonist 99.73%
    Epinastine hydrochloride (WAL801 hydrochloride) is an antihistamine and mast cell stabilizer. Epinastine hydrochloride is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine hydrochloride also inhibits IL-8 release and has an antiallergic action.
  • HY-14447
    Bilastine
    Antagonist 99.91%
    Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria.
  • HY-B2168
    Mequitazine
    Antagonist 99.99%
    Mequitazine is a potent, and long-acting histamine H1 antagonist.