Histamine Receptor Antagonist

Histamine Receptor Antagonists (229):

Cat. No.	Product Name	Effect	Purity

HY-12537

Peptide 401	Antagonist	98.26%
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

HY-19705B

Adriforant hydrochloride	Antagonist	≥98.0%
Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (K_i=2.4 nM) and is also a functional (K_i=1.56 nM) antagonist.

HY-B1693

Levomepromazine	Antagonist	99.98%
Levomepromazine (Methotrimeprazine) is an orally active antipsychotic compound and Ca²⁺ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca²⁺ levels. Levomepromazine has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine can induce adaptive ER stress and autophagy. In addition, Levomepromazine has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine can be used in the study psychiatric disorders and relieving nausea and vomiting.

HY-B1296

Promethazine	Antagonist	99.61%
Promethazine is an orally active histamine receptor antagonist. Promethazine is first-generation antihistamine of the phenothiazine family, shows strong sedative and weak antipsychotic effects.

HY-B0538A

Pemirolast potassium	Antagonist	99.93%
Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

HY-B0164

Mizolastine	Antagonist	99.82%
Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165, VEGF120, TNF-α and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial.

HY-14537

Latrepirdine dihydrochloride	Antagonist	99.65%
Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.

HY-B1303A

Mebhydrolin	Antagonist	99.78%
Mebhydrolin is a specific histamine H₁ receptor antagonist.

HY-15538

Ebrotidine	Antagonist	98.51%
Ebrotidine(FI 3542) is a competitive H2-receptor antagonist (Ki= 127.

HY-17610

Enerisant	Antagonist	99.79%
Enerisant (TS-091) is a potent, highly selective, competitive and orally active histamine H₃ receptor antagonist/inverse agonist with IC₅₀s of 2.89 nM and 14.5 nM against human and rat histamine H₃ receptors, respectively.

HY-B2168

Mequitazine	Antagonist	99.99%
Mequitazine is a potent, and long-acting histamine H₁ antagonist.

HY-B0286

Chlorpheniramine	Antagonist	99.86%
Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research.

HY-B1589A

Carbinoxamine maleate salt	Antagonist	99.81%
Carbinoxamine maleate salt is a histamine H1 receptor antagonist.

HY-B0160

Lafutidine	Antagonist	99.95%
Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H₂RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease.

HY-19489S

(±)-Levomepromazine-d₆	Antagonist	99.23%
(±)-Levomepromazine-d₆ is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.

HY-109074

Seliforant	Antagonist
Seliforant (SENS-111) is a selective and orally histamine H4 receptor antagonist.

HY-120124

Samelisant	Antagonist	98.65%
Samelisant (SUVN-G3031) is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant has a similar binding affinity towards human (hH3R; K_i=8.7 nM) and rat (rH3R;K_i=9.8 nM) H3R indicating no inter-species differences. Samelisant can be used for the research of sleep-related disorders.

HY-B1690A

Methdilazine hydrochloride	Antagonist	99.90%
Methdilazine hydrochloride is an orally active antibiotic (histamine antagonist). Methdilazine hydrochloride can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases.

HY-W010841R

Levocetirizine (dihydrochloride) (Standard)	Antagonist
Levocetirizine (dihydrochloride) (Standard) is the analytical standard of Levocetirizine (dihydrochloride). This product is intended for research and analytical applications. Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.

HY-30234S

Clemizole-d₄	Antagonist	99.82%
Clemizole-d4 is a deuterium labeled Clemizole. Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication.

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