1. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  2. Histamine Receptor 5-HT Receptor
  3. Peptide 401

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

For research use only. We do not sell to patients.

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Peptide 401 Chemical Structure

Peptide 401 Chemical Structure

CAS No. : 32908-73-9

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500 μg USD 135 In-stock
1 mg USD 220 In-stock
5 mg USD 550 In-stock
10 mg USD 825 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

IC50 & Target

serotonin

 

Histamine Receptor

 

In Vivo

Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins)[1]. Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcutaneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5- hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2587.22

Formula

C110H192N40O24S4

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)

Sequence Shortening

IKCNCKRHVIKPHICRKICGKN-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Peptide 401
Cat. No.:
HY-12537
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