1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
    5-HT Receptor
  3. Peptide 401

Peptide 401 

Cat. No.: HY-12537 Purity: 98.29%
Handling Instructions

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Peptide 401 Chemical Structure

Peptide 401 Chemical Structure

CAS No. : 32908-73-9

Size Price Stock Quantity
500 μg USD 336 In-stock
Estimated Time of Arrival: December 31
1 mg USD 576 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1980 In-stock
Estimated Time of Arrival: December 31
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50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

IC50 & Target

serotonin

 

Histamine Receptor

 

In Vivo

Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins)[1]. Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcutaneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5- hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2587.22

Formula

C₁₁₀H₁₉₂N₄₀O₂₄S₄

CAS No.

32908-73-9

Sequence

Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)

Sequence Shortening

IKCNCKRHVIKPHICRKICGKN-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

Peptide 401Peptide401Peptide-401Histamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Product Name:
Peptide 401
Cat. No.:
HY-12537
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