Triprolidine

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Triprolidine is an orally active H1R Antagonist antagonist. Triprolidine has the function of spinal cord motor and sensory block. Triprolidine can be used for the research of allergic rhinitis.

For research use only. We do not sell to patients.

Triprolidine Chemical Structure

CAS No. : 486-12-4

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Other In-stock Forms of Triprolidine:

Triprolidine hydrochloride monohydrate (E/Z)-Triprolidine-d₈ hydrochloride

Other Forms of Triprolidine:

Triprolidine hydrochloride monohydrate In-stock
(E/Z)-Triprolidine-d₈ hydrochloride In-stock
Triprolidine hydrochloride Get quote

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Description

Triprolidine is an orally active H1R Antagonist antagonist. Triprolidine has the function of spinal cord motor and sensory block. Triprolidine can be used for the research of allergic rhinitis^[1]^[2]^[3].

In Vitro

Triprolidine (maturing human dendritic cells) can antagonist histamine H1 and decreases the expression of CD45^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Triprolidine (292.81-1467.20 μg/kg; i.p.; Male Sprague-Dawley rat) produces a dose-dependent effect of spinal motor and sensory block in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rat (300-350 g)^[2]
Dosage:	292.81, 488.02, 733.60, 1098.83 and 1467.20 μg/kg
Administration:	Intrathecal injection
Result:	Elicited spinal block in a dose-dependent.

Molecular Weight

278.39

Formula

C₁₉H₂₂N₂

CAS No.

486-12-4

SMILES

CC1=CC=C(/C(C2=NC=CC=C2)=C\CN3CCCC3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Szeberényi JB, et, al. Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. Immunol Lett. 2001 Apr 2;76(3):175-82. [Content Brief]

[2]. Tzeng JI, et, al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661. [Content Brief]

[3]. Deal DL, Chandrasurin P, Shockcor J, Minick DJ, Findlay JW, McNulty MJ. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. 1992 Nov-Dec;20(6):920-7. [Content Brief]

Triprolidine Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triprolidine486-12-4Histamine Receptorantihistamineallergic rhinitisspinalmotorsensoryInhibitorinhibitorinhibit

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