1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Triprolidine hydrochloride

Triprolidine hydrochloride 

Cat. No.: HY-B1808A
Handling Instructions

Triprolidine hydrochloride, a first-generation antihistamine, is an orally active histamine H1 antagonist. Triprolidine hydrochloride can be used for the research of allergic rhinitis. Triprolidine hydrochloride exhibits spinal motor and sensory block in rats.

For research use only. We do not sell to patients.

Triprolidine hydrochloride Chemical Structure

Triprolidine hydrochloride Chemical Structure

CAS No. : 550-70-9

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Description

Triprolidine hydrochloride, a first-generation antihistamine, is an orally active histamine H1 antagonist. Triprolidine hydrochloride can be used for the research of allergic rhinitis. Triprolidine hydrochloride exhibits spinal motor and sensory block in rats[1][2][3].

IC50 & Target[1]

H1 Receptor

 

In Vivo

Triprolidine hydrochloride (292.81-1467.20 μg/kg; intrathecal injection) produces a dose-dependent effect of spinal motor and sensory block in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rat (300-350 g)[3]
Dosage: 292.81 μg/kg, 488.02 μg/kg, 733.60μg/kg, 1098.83 μg/kg, 1467.20 μg/kg
Administration: Intrathecal injection
Result: Elicited a dose-dependent spinal block.
Molecular Weight

314.85

Formula

C₁₉H₂₃ClN₂

CAS No.

550-70-9

SMILES

CC1=CC=C(/C(C2=NC=CC=C2)=C\CN3CCCC3)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TriprolidineHistamine Receptorantihistamineallergic rhinitisspinalmotorsensoryInhibitorinhibitorinhibit

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Triprolidine hydrochloride
Cat. No.:
HY-B1808A
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