1. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  2. Histamine Receptor
  3. Triprolidine hydrochloride

Triprolidine hydrochloride 

Cat. No.: HY-B1808A
Handling Instructions

Triprolidine hydrochloride is an orally active histamine H1 antagonist. Triprolidine hydrochloride has the function of spinal cord motor and sensory block. Triprolidine hydrochloride can be used for the research of allergic rhinitis.

For research use only. We do not sell to patients.

Triprolidine hydrochloride Chemical Structure

Triprolidine hydrochloride Chemical Structure

CAS No. : 550-70-9

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Description

Triprolidine hydrochloride is an orally active histamine H1 antagonist. Triprolidine hydrochloride has the function of spinal cord motor and sensory block. Triprolidine hydrochloride can be used for the research of allergic rhinitis[1][2][3].

IC50 & Target[1]

H1 Receptor

 

In Vitro

Triprolidine hydrochloride (maturing human dendritic cells) can antagonist histamine H1 and decreases the expression of CD45[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Triprolidine hydrochloride (292.81-1467.20 μg/kg; i.p.; Male Sprague-Dawley rat) produces a dose-dependent effect of spinal motor and sensory block in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rat (300-350 g)[2]
Dosage: 292.81, 488.02, 733.60, 1098.83 and 1467.20 μg/kg
Administration: Intrathecal injection
Result: Elicited a dose-dependent spinal block.
Molecular Weight

314.85

Formula

C19H23ClN2

CAS No.
SMILES

CC1=CC=C(/C(C2=NC=CC=C2)=C\CN3CCCC3)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Triprolidine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Triprolidine hydrochloride
Cat. No.:
HY-B1808A
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