1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Triprolidine hydrochloride monohydrate

Triprolidine hydrochloride monohydrate 

Cat. No.: HY-B1301 Purity: 99.87%
Handling Instructions

Triprolidine hydrochloride monohydrate is an orally active, cell-permeable and first-generation histamine H1 antagonist. Triprolidine hydrochloride monohydrate is an antihistamine and can be used in allergic rhinitis; asthma; and urticaria.

For research use only. We do not sell to patients.

Triprolidine hydrochloride monohydrate Chemical Structure

Triprolidine hydrochloride monohydrate Chemical Structure

CAS No. : 6138-79-0

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10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
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25 mg USD 95 In-stock
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50 mg USD 162 In-stock
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100 mg USD 275 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Triprolidine hydrochloride monohydrate is an orally active, cell-permeable and first-generation histamine H1 antagonist[1]. Triprolidine hydrochloride monohydrate is an antihistamine and can be used in allergic rhinitis; asthma; and urticaria[2].

IC50 & Target[1]

H1 Receptor

 

In Vivo

Triprolidine (intraseptal infusion; 0.5 μM in 0.5 μl; 30, 60, and 180 min after tetanus) had no significant effects on the baseline fEPSPs, however, it is followed by a smaller Long-term potentiation (LTP) induced during walking (173% of the baseline at 60 min) compared with saline infusion (208% at 60 min) in rats[2].

Animal Model: Adult male Long–Evans TMN (tuberomammillary nucleus (TMN) neurons) lesion rats[2]
Dosage: 0.5 μm in 0.5 μl
Administration: Intraseptal infusion; 30, 60, and 180 min after tetanus
Result: Attenuated the walking-associated enhancement of LTP.
Molecular Weight

332.87

Formula

C₁₉H₂₅ClN₂O

CAS No.

6138-79-0

SMILES

CC1=CC=C(/C(C2=NC=CC=C2)=C\CN3CCCC3)C=C1.[H]Cl.[H]O[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

Triprolidine hydrochlorideHistamine Receptorantihistaminesneezingrunny nosewatery eyehivesskin rashallergyheat strokeallergic rhinitisasthmaurticariaInhibitorinhibitorinhibit

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Triprolidine hydrochloride monohydrate
Cat. No.:
HY-B1301
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