486-12-4
486-12-4
Chemical Structure
Triprolidine
- CAS No.: 486-12-4
- Formula:C19H22N2
- Molecular Weight:278.39
IUPAC Name: (E)-2-(3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine
InChIKey: CBEQULMOCCWAQT-WOJGMQOQSA-N
SMILES: CC1=CC=C(/C(C2=NC=CC=C2)=C\CN3CCCC3)C=C1
Biological Activity: Triprolidine is an orally active H1R Antagonist antagonist. Triprolidine has the function of spinal cord motor and sensory block. Triprolidine can be used for the research of allergic rhinitis[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Triprolidine | 98.84% | Triprolidine is an orally active H1R Antagonist antagonist. Triprolidine has the function of spinal cord motor and sensory block. Triprolidine can be used for the research of allergic rhinitis. | ||||||||||||||||||||
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Pridefine | Pridefine (AHR-1118) is an antidepressant agent. | |||||||||||||||||||||
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PBPE hydrochloride (Standard) | PBPE hydrochloride (Standard) is the analytical standard of PBPE (hydrochloride) (HY-10830A). This product is intended for research and analytical applications. PBPE hydrochloride is a derivative of tamoxifen (HY-13757A) and a selective ligand for the anti-estrogen binding site (AEBS), the binding affinities (Ki) of PBPE hydrochloride and MBPE to AEBS are 8.79 and 17.57 nM, respectively. | |||||||||||||||||||||
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Zimelidine dihydrochloride (Standard) | ≥98% | Zimelidine dihydrochloride (Standard) is the analytical standard of Zimelidine dihydrochloride (HY-110023). This product is intended for research and analytical applications. Zimelidine dihydrochloride is an orally active selective serotonin reuptake inhibitor. Zimelidine dihydrochloride competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine dihydrochloride time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine dihydrochloride strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine dihydrochloride exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine dihydrochloride is used for the study of depressive disorders and analgesic tolerance. | ||||||||||||||||||||
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Zimelidine | Zimelidine is an orally active selective serotonin reuptake inhibitor. Zimelidine competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine is used for the study of depressive disorders and analgesic tolerance. | |||||||||||||||||||||
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Nomelidine | Nomelidine is the metabolite of Zimelidine (HY-118835), that exhibits antidepressant and analgesic properties. | |||||||||||||||||||||
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Triprolidine hydrochloride monohydrate | 99.82% | Triprolidine hydrochloride monohydrate, a first-generation antihistamine, is an oral active histamine H1 antagonist. Triprolidine hydrochloride monohydrate can be used for the research of allergic rhinitis. Triprolidine hydrochloride monohydrate exhibits spinal motor and sensory block in rats. | ||||||||||||||||||||
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Acrivastine | 99.86% | Acrivastine (BW825C) is a short acting histamine 1 receptor antagonist for the treatment of allergic rhinitis. | ||||||||||||||||||||
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Triprolidine hydrochloride | 99.76% | Triprolidine hydrochloride is an orally active histamine H1 antagonist. Triprolidine hydrochloride has the function of spinal cord motor and sensory block. Triprolidine hydrochloride can be used for the research of allergic rhinitis. | ||||||||||||||||||||
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(E/Z)-Triprolidine-d8 hydrochloride | (E/Z)-Triprolidine-d8 (hydrochloride) is the deuterium labeled (E/Z)-Triprolidine hydrochloride. | |||||||||||||||||||||
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1-(1,3-Diphenylpropan-2-yl)pyrrolidine hydrochloride | 1-(1,3-Diphenylpropan-2-yl)pyrrolidine hydrochloride is structurally similar to known dissociative anesthetics. | |||||||||||||||||||||
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References
- [1]. Szeberényi JB, et, al. Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. Immunol Lett. 2001 Apr 2;76(3):175-82. [Content Brief]
- [2]. Tzeng JI, et, al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661. [Content Brief]
- [3]. Deal DL, Chandrasurin P, Shockcor J, Minick DJ, Findlay JW, McNulty MJ. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. 1992 Nov-Dec;20(6):920-7. [Content Brief]
