Methapyrilene
Based on 1 Customer Validation
Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 91-80-5
- Formula: C14H19N3S
- Molecular Weight:261.39
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
>1000 μM
Compound: Methapyrilene
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Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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[PMID: 21965623] |
| Sf21 | IC50 |
>1000 μM
Compound: Methapyrilene
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Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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[PMID: 21965623] |
Methapyrilene (650 μM, 72 h) decreases the transcriptional level of transferrin and is accompanied by a decrease in transferrin protein levels in HepRG cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar derived AlpK:APfSD (Alderley Park) rats[2]
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Dosage:50 mg/kg, 150 mg/kg
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Administration:Gavage with water (vehicle), daily, 3 days
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Result:Showed mild to moderate periportal hepatocyte degeneration and necrosis as well as acute inflammatory cells were observed in the filtering periportal vein at a dose concentration of 150 mg/kg.
Decreased levels of both glucose and glycogen in the liver.
Showed higher levels of succinic acid and dimethylglycine of urine obtained from the low dose group of 50 mg/kg.
Chemical Information
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CAS No. 91-80-5
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Appearance Liquid
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Molecular Weight 261.39
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Formula C14H19N3S
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Color Colorless to light yellow
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SMILES
CN(C)CCN(C1=NC=CC=C1)CC2=CC=CS2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
References
[1]. Volodymyr Tryndyak, et al. Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. [Content Brief]
[2]. Andrew Craig, et al. Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J Proteome Res. 2006 Jul;5(7):1586-60 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methapyrilene Related Classifications
HY-111130 Related Classifications
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