1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Lafutidine

Lafutidine (Synonyms: FRG-8813)

Cat. No.: HY-B0160 Purity: 98.67%
Handling Instructions

Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease.

For research use only. We do not sell to patients.

Lafutidine Chemical Structure

Lafutidine Chemical Structure

CAS No. : 118288-08-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 74 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 74 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 67 In-stock
Estimated Time of Arrival: December 31
50 mg USD 163 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease[1].

IC50 & Target

Histamine H2-receptor[1]

In Vitro

Lafutidine exhibits gastric mucosal protective action mediated by capsaicin-sensitive afferent neurons, in addition to a potent antisecretory effect[2].
Lafutidine (0.1-10 µM) significantly augments the periarterial nerve stimulation (PNS, 1 Hz) induced-vasodilation in a concentration-dependent manner in rat perfused mesenteric vascular beds[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lafutidine (3-30 mg/kg; p.o.; twice daily; for 6 days) dose-dependently reduces the severity of dextran sulfate Na (DSS)-induced colitis and significantly mitigates changes in the colon length and myeloperoxidase (MPO) activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (180-200 g)[3]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Oral administration, twice daily, for 6 days
Result: Reduced the severity of DSS-induced ulcerative colitis in a dose-dependent manner.
Clinical Trial
Molecular Weight

431.55

Formula

C₂₂H₂₉N₃O₄S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (115.86 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3172 mL 11.5861 mL 23.1723 mL
5 mM 0.4634 mL 2.3172 mL 4.6345 mL
10 mM 0.2317 mL 1.1586 mL 2.3172 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (6.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (6.95 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (6.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Lafutidine
Cat. No.:
HY-B0160
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