1. GPCR/G Protein
    Neuronal Signaling
  2. Histamine Receptor
  3. (Z)-Lafutidine

(Z)-Lafutidine (Synonyms: (Z)-FRG-8813)

Cat. No.: HY-121406
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(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities.

For research use only. We do not sell to patients.

(Z)-Lafutidine Chemical Structure

(Z)-Lafutidine Chemical Structure

CAS No. : 206449-93-6

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(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities[1].

In Vivo

(Z)-Lafutidine (Compound 16) stimulates mucin biosynthesis in rat gastric mucosa and this effect not directly due to histamine H2 receptor antagonism[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight- to nine-week-old male C57BL/6 mice weighing 20-24g[1]
Dosage: 3-30 mg/kg
Administration: P.o; twice for 6 days (5-FU: 50 mg/kg; i.p.;once daily)
Result: Reduced the severity of diarrhea during 5-FU treatment,in a mostly dose-dependent manner, and a significant effect was observed at a dose of 30 mg/kg.
Molecular Weight







Room temperature in continental US; may vary elsewhere.


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