Isocitrate Dehydrogenase (IDH)
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Isocitrate Dehydrogenase (IDH) Related Products (44)
Related Products (44)
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GSK321
0 ImagesGSK321 is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular α-Hydroxyglutaric acid (2-HG) (HY-113038B), abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia (AML) and other cancers.
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DS-1001b
0 ImagesDS-1001b is an orally active, blood-brain permeable, potent IDH-1 (isocitrate dehydrogenase-1) mutant inhibitor. DS-1001b has antitumor activity.
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IDH1 Inhibitor 8
0 ImagesIDH1 Inhibitor 8 (91) is isocitrate dehydrogenase 1 (IDH1) inhibitor. IDH1 Inhibitor 8 can be used for the research of cancer.
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Oxalomalic acid trisodium
0 ImagesCat. No.: HY-131521CAS No.: 89304-26-7Synonyms: Oxalomalate trisodiumOxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages.
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(R,S)-Ivosidenib
0 ImagesSynonyms: (R,S)-AG-120(R,S)-Ivosidenib ((R,S)-AG-120) is a (R,S)-enantiomer of Ivosidenib (AG-120) with lower activity. Ivosidenib can be used in research on IDH1-mutant cancers.
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Isocitrate dehydrogenase (NAD+), Bacteria
0 ImagesCat. No.: HY-P2993BIsocitrate dehydrogenase (NAD+) , Bacteria (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone) , followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate.
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Isocitrate Dehydrogenase (NADP+), Bacteria
0 ImagesCat. No.: HY-P2993CIsocitrate Dehydrogenase (NADP+) , Bacteria (EC 1.1.1.42) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2.
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trans-3-(3-Pyridyl)acrylic acid
0 Imagestrans-3-(3-Pyridyl) acrylic acid is an unsaturated carboxylic acid and synthetic building block, which serves as a synthetic precursor of 3-(3-pyridyl) propanoic acid. trans-3-(3-Pyridyl) acrylic acid can be used to prepare dual mutant IDH1/NAMPT inhibitors and PGE2 antagonist analogs. In addition, trans-3-(3-Pyridyl) acrylic acid exhibits antiviral activity against tobacco mosaic virus (TMV).
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Isocitrate dehydrogenase, Porcine heart
0 ImagesIsocitrate dehydrogenase, Porcine heart (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P)+ to NAD(P)H, it plays important roles in cellular metabolism.
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IDH889
0 ImagesIDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM.
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ZD-2767P
0 ImagesCat. No.: HY-19208CAS No.: 156079-88-8ZD-2767P (Compound 1) is a reversible and competitive inhibitor of IDH1, with its IC50 value being 410 nM.
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IDH1 Inhibitor 1
0 ImagesIDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT, respectively. Anticancer activity.
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IDH1 Inhibitor 7-d2
0 ImagesIDH1 Inhibitor 7-d2 is the deuterium labeled IDH1 Inhibitor 7 (HY-150238). IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC50 of less than 100 nM.
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Mutant IDH1 inhibitor
0 ImagesMutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM.
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IDH1 Inhibitor 3
0 ImagesCat. No.: HY-107977CAS No.: 2171081-24-4IDH1 Inhibitor 3 (compound 6f) is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor, with an IC50 of 45 nM for IDH1R132H.
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(S,S)-GSK321
0 Images(S,S)-GSK321 is a (S,S)-enantiomer of GSK321.
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Mutant IDH1-IN-4
0 ImagesMutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells.
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Lanisidenib
0 ImagesCat. No.: HY-168980CAS No.: 2135537-20-9Lanisidenib is the inhibitor for isocitrate dehydrogenase that exhibits antineoplastic activity.
