Isocitrate Dehydrogenase (IDH)

Isocitrate Dehydrogenase (IDH) Related Products (43):

By Effects:	Inhibitors (31) Control (1)

Cat. No.	Product Name	Effect	Purity

HY-18948

GSK321	Inhibitor	99.87%
GSK321 is a potent, selective mutant IDH1 inhibitor with IC₅₀ values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular α-Hydroxyglutaric acid (2-HG) (HY-113038B), abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia (AML) and other cancers.

HY-129545

DS-1001b	Inhibitor	99.71%
DS-1001b is an orally active, blood-brain permeable, potent IDH-1 (isocitrate dehydrogenase-1) mutant inhibitor. DS-1001b has antitumor activity.

HY-41648

IDH1 Inhibitor 8	Inhibitor	99.83%
IDH1 Inhibitor 8 (91) is isocitrate dehydrogenase 1 (IDH1) inhibitor. IDH1 Inhibitor 8 can be used for the research of cancer.

HY-131521

Oxalomalic acid trisodium	Inhibitor
Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages.

HY-18767A

(R,S)-Ivosidenib	Control	98.01%
(R,S)-Ivosidenib ((R,S)-AG-120) is a (R,S)-enantiomer of Ivosidenib (AG-120) with lower activity. Ivosidenib can be used in research on IDH1-mutant cancers.

HY-186102

IDH1 ligand 1
IDH1 ligand 1 (Compound 18) can serve as a negative control for the IDH1 target, with no detectable affinity for wild-type IDH1 and an IC₅₀ >10,000 nM.

HY-E70965

Isocitric Dehydrogenase (NADP), Porcine
Isocitric Dehydrogenase (NADP), Porcine (EC 1.1.1.42) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2.

HY-P2993B

Isocitrate dehydrogenase (NAD+), Bacteria
Isocitrate dehydrogenase (NAD+) , Bacteria (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone) , followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate.

HY-W017463

trans-3-(3-Pyridyl)acrylic acid	Inhibitor	99.87%
trans-3-(3-Pyridyl) acrylic acid is an unsaturated carboxylic acid and synthetic building block, which serves as a synthetic precursor of 3-(3-pyridyl) propanoic acid. trans-3-(3-Pyridyl) acrylic acid can be used to prepare dual mutant IDH1/NAMPT inhibitors and PGE₂ antagonist analogs. In addition, trans-3-(3-Pyridyl) acrylic acid exhibits antiviral activity against tobacco mosaic virus (TMV).

HY-112289

IDH889	Inhibitor	99.96%
IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC₅₀s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1^R132H, IDH1^R132C and IDH1^wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC₅₀ of 0.014 μM.

HY-19208

ZD-2767P	Inhibitor
ZD-2767P (Compound 1) is a reversible and competitive inhibitor of IDH1, with its IC₅₀ value being 410 nM.

HY-P2993

Isocitrate dehydrogenase, Porcine heart
Isocitrate dehydrogenase, Porcine heart (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P)⁺ to NAD(P)H, it plays important roles in cellular metabolism.

HY-112601

IDH1 Inhibitor 1	Inhibitor	99.96%
IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC₅₀s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1^R132H, IDH1^R132C, and IDH1^WT, respectively. Anticancer activity.

HY-159833

Ranosidenib	Inhibitor
Ranosidenib is a isocitrate dehydrogenase (IDH) inhibitor with antitumor activity.

HY-150238S

IDH1 Inhibitor 7-d₂	Inhibitor	99.93%
IDH1 Inhibitor 7-d₂ is the deuterium labeled IDH1 Inhibitor 7 (HY-150238). IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC₅₀ of less than 100 nM.

HY-13972

Mutant IDH1 inhibitor	Inhibitor	99.08%
Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC₅₀ of < 72 nM.

HY-107977

IDH1 Inhibitor 3	Inhibitor
IDH1 Inhibitor 3 (compound 6f) is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor, with an IC₅₀ of 45 nM for IDH1^R132H.

HY-128888A

(S,S)-GSK321	Inhibitor	99.78%
(S,S)-GSK321 is a (S,S)-enantiomer of GSK321.

HY-114459

Mutant IDH1-IN-4	Inhibitor	≥99.0%
Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC₅₀ values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells.

HY-168980

Lanisidenib	Inhibitor
Lanisidenib is the inhibitor for isocitrate dehydrogenase that exhibits antineoplastic activity.

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