2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. ZD-2767P

ZD-2767P (Compound 1) is a reversible and competitive inhibitor of IDH1, with its IC50 value being 410 nM.

For research use only. We do not sell to patients.

ZD-2767P

ZD-2767P Chemical Structure

CAS No. : 156079-88-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Solid
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ZD-2767P Related Antibodies

Top Publications Citing Use of Products

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IDH1 IDH2

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Description

ZD-2767P (Compound 1) is a reversible and competitive inhibitor of IDH1, with its IC50 value being 410 nM[1].

Cellular Effect
Cell Line Type Value Description References
LoVo IC50
47.2 μM
Compound: 1b
Cytotoxicity against colorectal tumor cell line LoVo 1 hour after incubation.
Cytotoxicity against colorectal tumor cell line LoVo 1 hour after incubation.
[PMID: 8544182]
Molecular Weight

590.15

Formula

C16H20I2N2O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CC[C@@H](C(O)=O)NC(OC1=CC=C(N(CCI)CCI)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (42.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6945 mL 8.4724 mL 16.9448 mL
5 mM 0.3389 mL 1.6945 mL 3.3890 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6945 mL 8.4724 mL 16.9448 mL 42.3621 mL
5 mM 0.3389 mL 1.6945 mL 3.3890 mL 8.4724 mL
10 mM 0.1694 mL 0.8472 mL 1.6945 mL 4.2362 mL
15 mM 0.1130 mL 0.5648 mL 1.1297 mL 2.8241 mL
20 mM 0.0847 mL 0.4236 mL 0.8472 mL 2.1181 mL
25 mM 0.0678 mL 0.3389 mL 0.6778 mL 1.6945 mL
30 mM 0.0565 mL 0.2824 mL 0.5648 mL 1.4121 mL
40 mM 0.0424 mL 0.2118 mL 0.4236 mL 1.0591 mL
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ZD-2767P Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZD-2767P156079-88-8Isocitrate Dehydrogenase (IDH)ADEPT (Antibody Directed Enzyme Prodrug Therapy)apoptosiscarboxypeptidase G2 (CPG2)chlorambucilmonofunctional analoguecolorectal cancerInhibitorinhibitorinhibit

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