1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)
  3. IDH889

IDH889 

Cat. No.: HY-112289
Handling Instructions

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM.

For research use only. We do not sell to patients.

IDH889 Chemical Structure

IDH889 Chemical Structure

CAS No. : 1429179-07-6

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Description

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].

IC50 & Target

IC50: 0.02 μM (IDH1R132H), 0.072 μM (IDH1R132C), 1.38 μM (IDH1wt)[1]

Molecular Weight

436.48

Formula

C₂₃H₂₅FN₆O₂

CAS No.

1429179-07-6

SMILES

O=C1OC[[email protected]](C(C)C)N1C2=NC(N[[email protected]](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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IDH889
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