trans-3-(3-Pyridyl)acrylic acid

Cat. No.: HY-W017463 Purity: 99.87%: Data Sheet
COA

SDS
Handling Instructions
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trans-3-(3-Pyridyl) acrylic acid is an unsaturated carboxylic acid and synthetic building block, which serves as a synthetic precursor of 3-(3-pyridyl) propanoic acid. trans-3-(3-Pyridyl) acrylic acid can be used to prepare dual mutant IDH1/NAMPT inhibitors and PGE₂ antagonist analogs. In addition, trans-3-(3-Pyridyl) acrylic acid exhibits antiviral activity against tobacco mosaic virus (TMV).

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trans-3-(3-Pyridyl)acrylic acid 화학구조

CAS No. : 19337-97-4

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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View All Isoforms

IDH1 IDH2

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

At a concentration of 500 mg/mL (in vitro incubation), trans-3-(3-Pyridyl) acrylic acid exhibits an in vitro inhibition rate of 27.5% against Tobacco Mosaic Virus (TMV) in the anti-TMV in vitro inhibition assay, with inhibitory activity lower than that of the positive control ribavirin (HY-B0434)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

149.15

화학식

C₈H₇NO₂

CAS No.

19337-97-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(/C=C/C1=CC=CN=C1)O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 20 mg/mL (134.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7047 mL	33.5233 mL	67.0466 mL
5 mM	1.3409 mL	6.7047 mL	13.4093 mL
10 mM	0.6705 mL	3.3523 mL	6.7047 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

순도&문서

Purity: 99.87%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (245 KB) HNMR (119 KB) RP-HPLC (245 KB)

Handling Instructions (2659 KB)

References

[1]. Wu M, et al. Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents. PLoS One. 2013;8(2):e56475. [Content Brief]

[2]. Wen F, et al. Discovery of Novel Dual Inhibitors Targeting Mutant IDH1 and NAMPT for the Treatment of Glioma with IDH1Mutation. J Med Chem. 2024;67(11):8667-8692. [Content Brief]

[3]. Hallinan EA, et al. N-substituted dibenzoxazepines as analgesic PGE2 antagonists. J Med Chem. 1993;36(22):3293-3299. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.7047 mL	33.5233 mL	67.0466 mL	167.6165 mL
	5 mM	1.3409 mL	6.7047 mL	13.4093 mL	33.5233 mL
	10 mM	0.6705 mL	3.3523 mL	6.7047 mL	16.7617 mL
	15 mM	0.4470 mL	2.2349 mL	4.4698 mL	11.1744 mL
	20 mM	0.3352 mL	1.6762 mL	3.3523 mL	8.3808 mL
	25 mM	0.2682 mL	1.3409 mL	2.6819 mL	6.7047 mL
	30 mM	0.2235 mL	1.1174 mL	2.2349 mL	5.5872 mL
	40 mM	0.1676 mL	0.8381 mL	1.6762 mL	4.1904 mL
	50 mM	0.1341 mL	0.6705 mL	1.3409 mL	3.3523 mL
	60 mM	0.1117 mL	0.5587 mL	1.1174 mL	2.7936 mL
	80 mM	0.0838 mL	0.4190 mL	0.8381 mL	2.0952 mL
	100 mM	0.0670 mL	0.3352 mL	0.6705 mL	1.6762 mL