1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)
  3. IDH1 Inhibitor 3

IDH1 Inhibitor 3 (compound 6f) is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor, with an IC50 of 45 nM for IDH1R132H.

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IDH1 Inhibitor 3 Chemical Structure

IDH1 Inhibitor 3 Chemical Structure

CAS No. : 2171081-24-4

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Description

IDH1 Inhibitor 3 (compound 6f) is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor, with an IC50 of 45 nM for IDH1R132H[1].

IC50 & Target

IC50: 45 nM (IDH1R132H)[1].

Molecular Weight

591.56

Formula

C31H25F4N5O3

CAS No.
SMILES

O=C([C@@H](CC1)N(C2=NC=CC(C#N)=C2)C1=O)N([C@@]3(C(NC4CC(F)(F)C4)=O)CCC5=C3C=CC=C5)C6=CC(F)=CC(F)=C6

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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IDH1 Inhibitor 3 Related Classifications

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Help & FAQs
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
IDH1 Inhibitor 3
Cat. No.:
HY-107977
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