Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health^[1]^[2]^[3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets^[1]^[2]^[3].

References:

[1]. Seyedsayamdost MR. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):301-311.

[2]. Ruiz B, et al. Production of microbial secondary metabolites: regulation by the carbon source. Crit Rev Microbiol. 2010 May;36(2):146-67.

[3]. Wishart DS. Metabolomics for Investigating Physiological and Pathophysiological Processes. Physiol Rev. 2019 Oct 1;99(4):1819-1875.

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Related Products (8491)
Antibodies (477)
Endogenous Metabolite Isoform Comparison

By Effects:	Inhibitors (66) Agonists (3) Controls (2) Antagonist (1) Activators (7) Modulators (9) Chemicals (14) Inducers (6)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W018004R

L-Homocitrulline (Standard)
L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).

HY-W012846R

D-Threitol (Standard)
3,5-Dihydroxybenzoic acid (Standard) is the analytical standard of 3,5-Dihydroxybenzoic acid. This product is intended for research and analytical applications. 3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses.

HY-W778471

rac-1-Linoleoyl-3-linolenoyl-propanetriol		98.64%
1-Linoleoyl-3-α-linolenoyl-rac-glycerol is a diacylglycerol that contains linoleic acid (HY-N0729) at the sn-1 position and α-linolenic acid (HY-N0728) at the sn-3 position. It has been found in olive oil subjected to lipase-catalyzed glycerolysis with immobilized lipase B from C. antarctica.

HY-13677R

6-Mercaptopurine (Standard)
6-Mercaptopurine (Standard) is the analytical standard of 6-Mercaptopurine. This product is intended for research and analytical applications. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

HY-128532A

Formononetin 7-O-β-D-glucuronide sodium
Formononetin 7-O-β-D-glucuronide sodium is a metabolite of Formononetin (HY-N0183) and can be absorbed and metabolized through the intestine.

HY-N5034S

Phosphorylethanolamine-d₄		99.86%
Phosphorylethanolamine-d₄ (Monoaminoethyl phosphate-d₄; NSC 254167-d₄) is a deuterium labeled Phosphorylethanolamine (HY-N5034). Phosphorylethanolamine is an endogenous metabolite.

HY-150964S

S-Adenosyl-L-methionine-d₃ methylbenzenesulfonate
S-Adenosyl-L-methionine-d₃ (S-Adenosyl methionine-d₃) methylbenzenesulfonate is the deuterium labeled S-Adenosyl-L-methionine methylbenzenesulfonate. S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research.

HY-15130R

DL-O-Phosphoserine (Standard)
Jujuboside A (Standard) is the analytical standard of Jujuboside A. This product is intended for research and analytical applications. Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, a Chinese herbal medicine used to treat insomnia and anxiety.

HY-138615S1

Deoxythymidine-5'-triphosphate-¹⁵N₂ dilithium		99.0%
Deoxythymidine-5'-triphosphate-¹⁵N₂ (dTTP-¹⁵N₂) dilithium is ¹⁵N labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.

HY-165091

1,2-Dioctanoyl-3-decanoyl-rac-glycerol		99.0%
1,2-Dioctanoyl-3-decanoyl-rac-glycerol (1,2-Octanoin-3-decanoin) is a triglyceride identified in microalgae biomass by ion mobility-mass spectrometry. It can be used to characterize microalgae biomass. Different analytical strategies can determine its distribution in different microalgae and its relationship with other compounds, which has application value in biofuel production.

HY-128732

rel-(2R,3S)-2,3-Dihydroxysuccinic acid hydrate		99.96%
rel-(2R,3S)-2,3-Dihydroxysuccinic acid (hydrate) is an endogenous metabolite.

HY-113101R

2-Hydroxyadipic acid (Standard)
2-Amino-5-chlorobenzophenone (Standard) is the analytical standard of 2-Amino-5-chlorobenzophenone. This product is intended for research and analytical applications. 2-Amino-5-chlorobenzophenone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-B1227R

Carprofen (Standard)
Carprofen (Standard) is the analytical standard of Carprofen. This product is intended for research and analytical applications. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-W033823

Rhodium(III) oxide
Rhodium(III) oxide is an inorganic compound with catalytic activity. Rhodium(III) oxide can be used as an efficient catalyst in catalytic reactions and is often used to promote chemical reactions. Rhodium(III) oxide is also widely used in energy materials, especially in fuel cells and other renewable energy technologies. Rhodium(III) oxide is studied in the field of materials science for the development of new functional materials.

HY-130429

14,15-Leukotriene C4		98.9%
14,15-Leukotriene C4 (Eoxin C4) is a Leukotriene compound produced by the enzymatic reaction of arachidonic acid. 14,15-Leukotriene C4 has the activity of promoting inflammatory response. 14,15-Leukotriene C4 can increase the permeability of blood vessels, causing fluid and white blood cells to leak out of the blood vessels, which increases the number of inflammatory cells in the tissue. 14,15-Leukotriene C4 can be used in studies of asthma and other inflammatory diseases.

HY-W012589

tert-Pentylbenzene		98.85%
tert-Pentylbenzene (tert-Amylbenzene), a volatile aromatic hydrocarbon, is a fungal metabolite. tert-Pentylbenzene can be isolated from the saprophytic fungus Memnoniella sp. .

HY-113426S

Nepsilon-acetyl-L-lysine-d₈		98.52%
Nepsilon-acetyl-L-lysine-d₈ is the deuterium labeled Nepsilon-Acetyl-L-lysine. Nepsilon-Acetyl-L-lysine, an endogenous metabolite, is an R-chain N-acetylated α amino acid.

HY-N2149R

Tomatidine (Standard)
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans.

HY-W005288S

4-Vinylphenol-d₄
4-Vinylphenol-d₄ is deuterated labeled 4-Vinylphenol (HY-W005288). 4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo.

HY-W016813R

trans-Aconitic acid (Standard)
trans-Aconitic acid (Standard) is the analytical standard of trans-Aconitic acid. This product is intended for research and analytical applications. trans-Aconitic acid is present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aconitate 2-methyltransferase.

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Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Related Products (8491)

Antibodies (477)

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Related Products (8491):