4-Vinylphenol-d₄

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
4-Vinylphenol (12.5-200 μg/mL) significantly reduces cell viability in parental MDA-MB-231 cells, and the IC50 value is 109 μg/mL^[2].
4-Vinylphenol (0.15 or 0.3 μg/mL; 3 days) reduces sphere formation and vimentin expression on CSCs in breast cancer^[2].
4-Vinylphenol (50, 100 μg/mL; 72 hours) significantly suppresses cell proliferation in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol significantly reduces ALDH1A1 expression by 50% in CSC-enriched MDA-MB-231 cells^[2].
4-Vinylphenol (100 μg/mL) significantly increases the expressions of caspase 3, likely sensitizing CSC-enriched MDAMB-231 cells to apoptosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.