Endogenous Metabolite

Related Products

Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health^[1]^[2]^[3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets^[1]^[2]^[3].

References:

[1]. Seyedsayamdost MR. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):301-311.

[2]. Ruiz B, et al. Production of microbial secondary metabolites: regulation by the carbon source. Crit Rev Microbiol. 2010 May;36(2):146-67.

[3]. Wishart DS. Metabolomics for Investigating Physiological and Pathophysiological Processes. Physiol Rev. 2019 Oct 1;99(4):1819-1875.

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Related Products (8491)
Antibodies (477)
Endogenous Metabolite Isoform Comparison

By Effects:	Inhibitors (66) Agonists (3) Controls (2) Antagonist (1) Activators (7) Modulators (9) Chemicals (14) Inducers (6)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-141635

cis-11,14-Eicosadienoic acid methyl ester		98.05%
cis-11,14-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid, a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki=3.1 μM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki=3.0 μM). Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.3 Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.

HY-128748R

DL-Glyceraldehyde (Standard)
DL-Glyceraldehyde (Standard) is the analytical standard of DL-Glyceraldehyde. This product is intended for research and analytical applications. DL-Glyceraldehyde is a bioactive substance involved in cellular energy metabolism and a key intermediate in sugar metabolism pathways (such as glycolysis and gluconeogenesis). During glycolysis, DL-Glyceraldehyde is converted by enzymes into other metabolites to provide energy for cells; during gluconeogenesis, DL-Glyceraldehyde participates in the synthesis of glucose as a precursor. In the field of medical research, DL-Glyceraldehyde can be used to study diseases related to sugar metabolism, such as diabetes, tumors, etc.

HY-D0184S6

2'-Deoxycytidine-¹³C,¹⁵N₃
2'-Deoxycytidine-¹³C,¹⁵N₃ (Deoxycytidine-¹³C,¹⁵N₃) is ¹³C and ¹⁵N labeled 2'-Deoxycytidine. 2'-Deoxycytidine, a deoxyribonucleoside, can inhibit biological effects of Bromodeoxyuridine (Brdu). 2'-Deoxycytidine is essential for the synthesis of nucleic acids, that can be used for the research of cancer.

HY-N13266

5β-Cholestane-3α,7α,12α,25,27-pentol
5β-Cholestane-3α,7α,12α,25,27-pentol is a bile alcohol found in amphibian bile. 5β-Cholestane-3α,7α,12α,25,27-pentol serves as a principal or sole constituent of sulfate-conjugated bile salts in gallbladder bile of the caecilian Dermophis mexicanus. 5β-Cholestane-3α,7α,12α,25,27-pentol appears as a minor constituent in bile of the toad Bufo b. formosus. 5β-Cholestane-3α,7α,12α,25,27-pentol may represent the end product of cholesterol metabolism in the caecilian, as bile acids remain undetected in this organism.

HY-152007S

Butyrylcarnitine-d₃ hydrochloride
Butyrylcarnitine-d₃ hydrochloride is deuterium labeled Butyrylcarnitine (HY-113168). Butyrylcarnitine is an endogenous metabolite found in plasma. Elevated levels of Butyrylcarnitine are closely associated with abnormalities in lipid and energy metabolism. Butyrylcarnitine can serve as a diagnostic and prognostic indicator for certain diseases, such as heart failure and head and neck cancer.

HY-113345R

Zymostenol (Standard)
Oxyphenbutazone (monohydrate) (Standard) is the analytical standard of Oxyphenbutazone (monohydrate). This product is intended for research and analytical applications. Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis.

HY-N7312

Ditryptophenaline
Ditryptophenaline ((-)-Ditryptophenaline) is a secondary metabolite. Ditryptophenaline can be isolated from Aspergillus flavus. Ditryptophenaline inhibits the Substance P receptor. Ditryptophenaline exhibits potential analgesic and anti-inflammatory activities.

HY-113047R

5,6-Dihydrouridine (Standard)
5,6-Dihydrouridine (Standard) is the analytical standard of 5,6-Dihydrouridine. This product is intended for research and analytical applications. 5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.

HY-176157

12S(13R)-EpODE(γ)
12S(13R)-EpODE(γ) (12S(13R)-Epoxy-γ-octadecadienoic acid) is an epoxy-fatty acid.

HY-115513

Pitstop 1
Pitstop 1 is a small molecule inhibitor with endocytosis-inhibiting activity. Pitstop 1 blocks the interaction of chaperones with the Krasin terminal domain in cells, thereby affecting the function of Krasin. Pitstop 1 exhibits superior biological activity in significantly inhibiting the effects of Krasin. Pitstop 1 acts as a dose that inhibits the entry of viruses and pathogens into cells and modulates cell signaling.

HY-W714675

Glucoiberin
Glucoiberin is a glucosinolate found in Brassica oleracea. Hydrolysis products of Glucoiberin exhibit anticancer activity.

HY-N11189

α-D-Ribose-5-phosphate	Chemical
α-D-Ribose-5-phosphate is an important intermediate metabolite in the pentose phosphate pathway and in the purine metabolism pathway.

HY-W012340R

H-HomoArg-OH.HCl (Standard)
H-HomoArg-OH.HCl is an endogenous metabolite.

HY-Y1125R

6-Methyluracil (Standard)
6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo.

HY-165078

(±)11(12)-EpETE
(±)11(12)-EpETE ((±)11,12-EEQ) is an EPA hydroxyl product. EPA is a major component of Omega-3 polyunsaturated fatty acids (PUFAs).

HY-124422R

Pentacosanoic acid (Standard)
Pentacosanoic acid (Standard) is the analytical standard of Pentacosanoic acid. This product is intended for research and analytical applications. Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate[1].

HY-N13198

4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside
4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside is a pancreatic lipase inhibitor, with an IC₅₀ value of 2.91 μM. 4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside can effectively reduce lipid absorption and regulate obesity-related metabolic disorders, making it useful for research on obesity.

HY-W012479R

H-D-Trp-OH (Standard)
H-D-Trp-OH (Standard) is the analytical standard of H-D-Trp-OH. This product is intended for research and analytical applications. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.

HY-N18989

Cyclo(L-Ile-D-Leu)
Cyclo (L-Ile-D-Leu) (Compound 15) is a STAT3 inhibitor. Cyclo (L-Ile-D-Leu) is isolated from the culture broth of Lactococcus lactis KR-050L. Cyclo (L-Ile-D-Leu) inhibits IL-6-induced STAT3 activation in cancer cells. Cyclo (L-Ile-D-Leu) is applicable to hepatocellular carcinoma research.

HY-W708469

Resolvin D2 methyl ester
Resolvin D2 methyl ester is an ester derivative of the DHA (HY-B2167) metabolite Resolvin D2 (HY-121636) with anti-inflammatory and anti-infective activities. Resolvin D2 is a leukocyte modulator and a potent inhibitor of neuronal TRPV1 (IC₅₀=0.1 nM) and TRPA1 (IC₅₀=2 nM). Resolvin D2 can be used in sepsis research.

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Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Related Products (8491)

Antibodies (477)

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Related Products (8491):