Cyclo(L-Ile-D-Leu)
Cyclo (L-Ile-D-Leu) (Compound 15) is a STAT3 inhibitor. Cyclo (L-Ile-D-Leu) is isolated from the culture broth of Lactococcus lactis KR-050L. Cyclo (L-Ile-D-Leu) inhibits IL-6-induced STAT3 activation in cancer cells. Cyclo (L-Ile-D-Leu) is applicable to hepatocellular carcinoma research.
For research use only. We do not sell to patients.
- CAS No.: 2193113-02-7
- Formula: C12H22N2O2
- Molecular Weight:226.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Microbial Metabolite |
IL-6 |
STAT3 |
Cyclo(L-Ile-D-Leu) (30-60 μg mol l-1; 12-48 h) moderately inhibits IL-6-induced STAT3 activation in Hep3B cells, with 37.75% inhibition at 30 μg mol l-1 and 38.94% inhibition at 60 μg mol l-1, and shows no cytotoxicity at these concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2193113-02-7
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Molecular Weight 226.32
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Formula C12H22N2O2
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SMILES
CC[C@H]([C@]1([H])C(N[C@H](C(N1)=O)CC(C)C)=O)C
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Structure Classification
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Initial Source
Lactobacillus curvatus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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