2. JAK/STAT Signaling Stem Cell/Wnt Immunology/Inflammation Metabolic Enzyme/Protease
  3. STAT Interleukin Related Endogenous Metabolite
  4. Cyclo(L-Ile-D-Leu)

Cyclo (L-Ile-D-Leu) (Compound 15) is a STAT3 inhibitor. Cyclo (L-Ile-D-Leu) is isolated from the culture broth of Lactococcus lactis KR-050L. Cyclo (L-Ile-D-Leu) inhibits IL-6-induced STAT3 activation in cancer cells. Cyclo (L-Ile-D-Leu) is applicable to hepatocellular carcinoma research.

For research use only. We do not sell to patients.

Cyclo(L-Ile-D-Leu)

Cyclo(L-Ile-D-Leu) Chemical Structure

CAS No. : 2193113-02-7

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Cyclo(L-Ile-D-Leu) Related Antibodies

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Description

Cyclo (L-Ile-D-Leu) (Compound 15) is a STAT3 inhibitor. Cyclo (L-Ile-D-Leu) is isolated from the culture broth of Lactococcus lactis KR-050L. Cyclo (L-Ile-D-Leu) inhibits IL-6-induced STAT3 activation in cancer cells. Cyclo (L-Ile-D-Leu) is applicable to hepatocellular carcinoma research[1].

IC50 & Target[1]

Microbial Metabolite

 

IL-6

 

STAT3

 

In Vitro

Cyclo(L-Ile-D-Leu) (30-60 μg mol l-1; 12-48 h) moderately inhibits IL-6-induced STAT3 activation in Hep3B cells, with 37.75% inhibition at 30 μg mol l-1 and 38.94% inhibition at 60 μg mol l-1, and shows no cytotoxicity at these concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclo(L-Ile-D-Leu) Related Antibodies
Molecular Weight

226.32

Formula

C12H22N2O2
CAS No.
SMILES

CC[C@H]([C@]1([H])C(N[C@H](C(N1)=O)CC(C)C)=O)C
Structure Classification
Initial Source

Lactobacillus curvatus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cyclo(L-Ile-D-Leu) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(L-Ile-D-Leu)2193113-02-7STATInterleukin RelatedEndogenous MetaboliteILHep3B cellsIL-6Lactococcus lactis KR-050Lcancer cellsSTAT3Inhibitorinhibitorinhibit

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