2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers
  5. Alkyl-Chain Linkers Isoform

Alkyl-Chain Linkers

Alkyl-chain linkers function as flexible hydrophobic spacers that connect two binding elements in PROTACs, thereby positioning the protein of interest and E3 ligase for ternary-complex formation and ubiquitin-proteasome degradation[1][2]. Mechanistically, linker length and composition regulate PROTAC physicochemical properties, bioactivity, permeability, and degradation performance[1][3][4]. In disease-relevant targeted protein degradation models, linker optimization supports evaluation of permeability and target degradation rather than simple binary binding[3][4]. Compared with PEG linkers, alkyl linkers provide a hydrophobic and conformationally distinct linker class, while excessive flexibility or suboptimal length can reduce productive ternary-complex geometry[1][2]. For experimental applications, alkyl-chain linker libraries support rapid structure-activity relationship studies, permeability screening, and degradation assays in PROTAC discovery workflows[3][4]. In ADC research, linker chemistry also controls circulation stability and payload release, showing that linker design broadly governs delivery performance across conjugated therapeutic platforms[5][6]. - Alkyl-chain linkers tune PROTAC geometry, permeability, and degradation through length and composition. - PEG and alkyl linkers differ in hydrophilicity, flexibility, and conformational behavior. - Linker libraries enable practical SAR studies for degrader and conjugate design.

Alkyl-Chain Linkers 관련 제품 (86):

Cat. No. 상품명 CAS No. Purity 화학구조
  • HY-118411
    5-Ethynyl-2'-deoxyuridine 61135-33-9 99.78%
    5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5-Ethynyl-2'-deoxyuridine
  • HY-W008574
    TGN-020 51987-99-6 99.97%
    TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats.
    TGN-020
  • HY-140346A
    L-Azidohomoalanine hydrochloride 942518-29-8 98.85%
    L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    L-Azidohomoalanine hydrochloride
  • HY-141128
    Ac4GalNAz 653600-56-7 99.99%
    Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Ac4GalNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Ac4GalNAz
  • HY-W040304
    Alkynyl Palmitic Acid 99208-90-9 99.90%
    Alkynyl Palmitic Acid (Alk-C16) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Alkynyl Palmitic Acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkynyl Palmitic Acid
  • HY-140345
    L-Homopropargylglycine 98891-36-2 98.0%
    L-Homopropargylglycine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor.
    L-Homopropargylglycine
  • HY-40171
    NH2-C2-NH-Boc 57260-73-8 99.52%
    NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-C2-NH-Boc
  • HY-140335
    Alkynyl myristic acid 82909-47-5
    Alkynyl myristic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Alkynyl myristic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkynyl myristic acid
  • HY-140341
    Sulfo-NHS-Acetate 152305-87-8 98.0%
    Sulfo-NHS-Acetate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Sulfo-NHS-Acetate
  • HY-123916
    DBCO-Biotin 1418217-95-4 98.49%
    DBCO-Biotin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-Biotin
  • HY-107608
    Leukotriene B4 71160-24-2 ≥98.0%
    Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Leukotriene B4
  • HY-W004710
    NH2-C5-NH-Boc 51644-96-3 99.59%
    NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-C5-NH-Boc
  • HY-W013458
    Bis(2-bromoethyl) ether 5414-19-7 99.91%
    Bis2-bromoethyl ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis(2-bromoethyl) ether
  • HY-141274
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol 58884-35-8
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol
  • HY-Y0786
    1,3-Dibromo-5,5-dimethylhydantoin 77-48-5 99.20%
    1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    1,3-Dibromo-5,5-dimethylhydantoin
  • HY-141186
    TCO-OH 85081-69-2 99.91%
    TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    TCO-OH
  • HY-42145
    3-Maleimidopropionic acid 7423-55-4 99.83%
    3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    3-Maleimidopropionic acid
  • HY-140345A
    L-Homopropargylglycine hydrochloride 942518-19-6 98.0%
    L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor.
    L-Homopropargylglycine hydrochloride
  • HY-141263
    Methyltetrazine-acid 1380500-88-8 99.75%
    Methyltetrazine-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-acid
  • HY-130893
    Biotin-EDA 111790-37-5 99.76%
    Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-EDA