Biotin-EDA
Based on 1 Customer Validation
Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 111790-37-5
- Formula: C12H22N4O2S
- Molecular Weight:286.39
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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Alkyl-Chain |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 111790-37-5
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Appearance Solid
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Molecular Weight 286.39
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Formula C12H22N4O2S
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Color White to off-white
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SMILES
O=C(NCCN)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (174.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4917 mL | 17.4587 mL | 34.9174 mL | 87.2935 mL |
| 5 mM | 0.6983 mL | 3.4917 mL | 6.9835 mL | 17.4587 mL | |
| 10 mM | 0.3492 mL | 1.7459 mL | 3.4917 mL | 8.7294 mL | |
| 15 mM | 0.2328 mL | 1.1639 mL | 2.3278 mL | 5.8196 mL | |
| 20 mM | 0.1746 mL | 0.8729 mL | 1.7459 mL | 4.3647 mL | |
| 25 mM | 0.1397 mL | 0.6983 mL | 1.3967 mL | 3.4917 mL | |
| 30 mM | 0.1164 mL | 0.5820 mL | 1.1639 mL | 2.9098 mL | |
| 40 mM | 0.0873 mL | 0.4365 mL | 0.8729 mL | 2.1823 mL | |
| 50 mM | 0.0698 mL | 0.3492 mL | 0.6983 mL | 1.7459 mL | |
| 60 mM | 0.0582 mL | 0.2910 mL | 0.5820 mL | 1.4549 mL | |
| 80 mM | 0.0436 mL | 0.2182 mL | 0.4365 mL | 1.0912 mL | |
| 100 mM | 0.0349 mL | 0.1746 mL | 0.3492 mL | 0.8729 mL |
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