1,3-Dibromo-5,5-dimethylhydantoin

Cat. No.: HY-Y0786 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

1,3-Dibromo-5,5-dimethylhydantoin Chemical Structure

CAS No. : 77-48-5

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Free Sample (0.1 - 0.5 mg)		Apply Now
500 g	USD 40	In-stock	Estimated Time of Arrival: December 31
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Description

1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

285.92

Formula

C₅H₆Br₂N₂O₂

CAS No.

77-48-5

Appearance

Solid

Color

White to light yellow

SMILES

O=C1N(Br)C(C(C)(C)N1Br)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (349.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4975 mL	17.4874 mL	34.9748 mL
5 mM	0.6995 mL	3.4975 mL	6.9950 mL
10 mM	0.3497 mL	1.7487 mL	3.4975 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (248 KB) SDS (941 KB)

COA (255 KB) HNMR (115 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4975 mL	17.4874 mL	34.9748 mL	87.4370 mL
	5 mM	0.6995 mL	3.4975 mL	6.9950 mL	17.4874 mL
	10 mM	0.3497 mL	1.7487 mL	3.4975 mL	8.7437 mL
	15 mM	0.2332 mL	1.1658 mL	2.3317 mL	5.8291 mL
	20 mM	0.1749 mL	0.8744 mL	1.7487 mL	4.3719 mL
	25 mM	0.1399 mL	0.6995 mL	1.3990 mL	3.4975 mL
	30 mM	0.1166 mL	0.5829 mL	1.1658 mL	2.9146 mL
	40 mM	0.0874 mL	0.4372 mL	0.8744 mL	2.1859 mL
	50 mM	0.0699 mL	0.3497 mL	0.6995 mL	1.7487 mL
	60 mM	0.0583 mL	0.2915 mL	0.5829 mL	1.4573 mL
	80 mM	0.0437 mL	0.2186 mL	0.4372 mL	1.0930 mL
	100 mM	0.0350 mL	0.1749 mL	0.3497 mL	0.8744 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,3-Dibromo-5,5-dimethylhydantoin77-48-5Inhibitorinhibitorinhibit

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1,3-Dibromo-5,5-dimethylhydantoin