DBCO-Biotin
Based on 1 Customer Validation
DBCO-Biotin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 97.42%
- CAS No.: 1418217-95-4
- Formula: C28H30N4O3S
- Molecular Weight:502.63
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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Alkyl-Chain |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1418217-95-4
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Appearance Solid
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Molecular Weight 502.63
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Formula C28H30N4O3S
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Color White to off-white
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SMILES
O=C1N[C@](CS2)([H])[C@@](N1)([H])[C@@H]2CCCCC(NCCC(N3C4=CC=CC=C4C#CC5=CC=CC=C5C3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 31.25 mg/mL (62.17 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9895 mL | 9.9477 mL | 19.8954 mL | 49.7384 mL |
| 5 mM | 0.3979 mL | 1.9895 mL | 3.9791 mL | 9.9477 mL | |
| 10 mM | 0.1990 mL | 0.9948 mL | 1.9895 mL | 4.9738 mL | |
| 15 mM | 0.1326 mL | 0.6632 mL | 1.3264 mL | 3.3159 mL | |
| 20 mM | 0.0995 mL | 0.4974 mL | 0.9948 mL | 2.4869 mL | |
| 25 mM | 0.0796 mL | 0.3979 mL | 0.7958 mL | 1.9895 mL | |
| 30 mM | 0.0663 mL | 0.3316 mL | 0.6632 mL | 1.6579 mL | |
| 40 mM | 0.0497 mL | 0.2487 mL | 0.4974 mL | 1.2435 mL | |
| 50 mM | 0.0398 mL | 0.1990 mL | 0.3979 mL | 0.9948 mL | |
| 60 mM | 0.0332 mL | 0.1658 mL | 0.3316 mL | 0.8290 mL |
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