Parasite Inhibitor

Parasite Inhibitors (2050):

Cat. No.	Nom du produit	Effet	Pureté

HY-B0777R

Moxidectin (Standard)	Inhibitor
Moxidectin (Standard) is the analytical standard of Moxidectin. This product is intended for research and analytical applications. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk.

HY-B1221S

Flufenamic acid-d₄	Inhibitor
Flufenamic acid-d₄ is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-P10390

Insecticidal agent 11	Inhibitor
Insecticidal agent 11 (compound Q6) is a potent insect growth regulator (IGR)-based insecticide. Insecticidal agent 11 shows high insecticidal activity against Diploptera punctata by inhibiting juvenile hormone (JH) biosynthesis. Insecticidal agent 11 also exhibits insecticidal activity against Plutella xylostella.

HY-147371

Quinoprazine	Inhibitor
Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC₅₀ value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrP^{S^c} levels^-.

HY-N0110R

Palmatine chloride (Standard)	Inhibitor
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.

HY-121328

Empenthrin	Inhibitor
Empenthrin (S-2852F) is a synthetic pyrethroid. Empenthrin can be used in insecticides. Empenthrin shows a clear species-specificity in the inhibitory effect on the Pentobarbital (PTB)-metabolizing enzyme(s). Empenthrin prolongs PTB induced-sleeping time in mice through an inhibition of the PTB-metabolizing enzyme(s) in the liver, an effect that does not occur in rats. Empenthrin shows a clear species-specificity in the inhibitory effect on the PTB-metabolizing enzyme(s).

HY-N8521

6-O-Methacrylate	Inhibitor
6-O-Methacrylate, a trilobolide, is isolated from the leaves of Wedelia trilobata. 6-O-Methacrylate displays marked antimalarial activity, with IC₅₀ of 8.9 μg/mL against P. falciparum parasite. 6-O-Methacrylate also has anti-tobacco mosaic virus (TMV) activity.

HY-149957

Antileishmanial agent-16	Inhibitor
Antileishmanial agent-16 (compound 14c) is an anti-Leishmania agent. Antileishmanial agent-16 has superior anti-Leishmania major promastigotes activity (IC₅₀ = 0.59 µM) and anti-Leishmania major amastigotes activity (IC₅₀ = 0.81 µM). Antileishmanial agent-16 has good safety to mammalian cells (VERO cells).

HY-N2434R

[10]-Shogaol (Standard)	Inhibitor
-Shogaol (Standard) is the analytical standard of -Shogaol (HY-N2434). This product is intended for research and analytical applications. [10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC₅₀ value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis.

HY-B0357R

Diclazuril (Standard)	Inhibitor
Diclazuril (Standard) is the analytical standard of Diclazuril. This product is intended for research and analytical applications. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.

HY-W663230

Eugenitin	Inhibitor
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD₅₀=39.9 μM. Eugenitin has low cytotoxicity (IC₅₀ >131 μM) against several human cancer cell lines.

HY-155207

Antileishmanial agent-23	Inhibitor
Antileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC₅₀ of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei.

HY-180433

Sulfiflumin	Inhibitor
Sulfiflumin (compound I) is a thiazolidine acaricide. Sulfiflumin can be used as a plant protection agent.

HY-153732

Insecticidal agent 2	Inhibitor
Insecticidal agent 2 (example 2) is a pesticide that exhibits potent growth-retarding activity against pests.

HY-N0059S6

D-Arabinose-d₆	Inhibitor
D-Arabinose-d₆ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082).

HY-108387

Morantel citrate	Inhibitor
Morantel citrate is a veterinary anthelmintic agent that inhibits parasitic infections in cattle, sheep and goats. Morantel citrate paralyzes the nervous system of the parasite, helping the animal expel the dead parasite from the body.

HY-117419

(-)-Lavandulyl acetate	Inhibitor
(-)-Lavandulyl acetate is a nature product that can be found in Lavandula angustifolia. (-)-Lavandulyl acetate shows toxicity for mosquito vectors. (-)-Lavandulyl acetate can be used as mosquito larvicide.

HY-147535

Antileishmanial agent-7	Inhibitor
Antileishmanial agent-7 (compound 23) is a potent antileishmanial agent. Antileishmanial agent-7 shows antileishmanial activity against Leishmania donovani and L-6, with IC₅₀ values of 6.89 and 259 μM, respectively.

HY-143322

CRK12-IN-2	Inhibitor
CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC₅₀ values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis.

HY-123686

Ivermectin B1a monosaccharide	Inhibitor
Ivermectin B1a monosaccharide is a modified Ivermectin B1a (HY-126937). Ivermectin B1a monosaccharide is an antiparasite agent with a minimum concentration for full activity in Haemonchus contortus larval development of 0.001 μg/mL.

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