Antileishmanial agent-16
Antileishmanial agent-16 (compound 14c) is an anti-Leishmania agent. Antileishmanial agent-16 has superior anti-Leishmania major promastigotes activity (IC50 = 0.59 µM) and anti-Leishmania major amastigotes activity (IC50 = 0.81 µM). Antileishmanial agent-16 has good safety to mammalian cells (VERO cells).
For research use only. We do not sell to patients.
- CAS No.: 2934738-41-5
- Formula: C27H37N5O4
- Molecular Weight:495.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
Leishmania[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
252.2 μM
Compound: 14c
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Cytotoxicity against green monkey Vero cells incubated for 72 hrs by crystal violet staining analysis
Cytotoxicity against green monkey Vero cells incubated for 72 hrs by crystal violet staining analysis
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[PMID: 37031526] |
Antileishmanial agent-16 (0-20 µM; 24 h) shows superior activity to againsts L. Major promastigote and amastigote forms, with IC50s of 0.59 and 0.81 µM, respectively[1].
Antileishmanial agent-16 shows high selectivity towards L. amastigote as well as their safety on mammalian cells (VERO cells), with anSI value of 311.4[1].
Selectivity indice (SI): the ratio between the in vitro cytotoxic activity (CC50 in μM) and the antileishmanial activity against amastigote form (unit of IC50: μM).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Promastigote and amastigote forms of Leishmania major strain
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Concentration:0-20 µM
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Incubation Time:24 h
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Result:Inhibited L. Major promastigote and amastigote forms, with IC50s of 0.59 and 0.81 µM, respectively.
Chemical Information
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CAS No. 2934738-41-5
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Molecular Weight 495.61
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Formula C27H37N5O4
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SMILES
CCCCOC1=CC2=C(C=C(C(O2)=O)C(NCCCCCCN3C=C(N=N3)CN4CCCC4)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-16 Related Classifications
HY-149957 Related Classifications
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