2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphatase

Phosphatase

Phosphatase

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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W013755
    Dioctyl phthalate
    		Activator 99.40%
    Dioctyl phthalate (DNOP) is a plasticizer. Dioctyl phthalate increases the activities of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in the liver, as well as the levels of creatinine and urea in the kidney. Exposure to Dioctyl phthalate disrupts the homeostasis of the intestinal microbial community, increases the abundance of pathogenic bacteria, and reduces the abundance of beneficial bacteria such as Lactobacillus. Dioctyl phthalate induces significant and dose-dependent inflammatory responses in the liver, spleen and kidney of mice.
    Dioctyl phthalate
  • HY-N8200
    Cassiaside B2
    		Inhibitor 99.68%
    Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist...
    Cassiaside B2
  • HY-W335972
    N-Lauryldiethanolamine
    		Inhibitor 98.0%
    N-Lauryldiethanolamine is an antistatic agent with a strong inhibitory effect on cell growth at 30 μM, showing some lysosomotropic behavior. N-Lauryldiethanolamine is toxic at a concentration of ≥10 μM in the osteogenesis inhibition assay.
    N-Lauryldiethanolamine
  • HY-124478
    Ethyl gentisate
    		Activator 99.97%
    Ethyl gentisate (Ethyl 2,5-dihydroxybenzoate) is a dual modulator for cell differentiation, that enhances the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and alkaline phosphatase activity, inhibits RANKL-activated osteoclastogenesis in RAW264.7 cells, and balances the bone remodeling process.
    Ethyl gentisate
  • HY-W102931
    6,7-Dichloroquinoline-5,8-dione
    		Inhibitor 98.26%
    6,7-Dichloroquinoline-5,8-dione (compound DA3002) is a potent CDC25B2 inhibitor with an IC50 value of 4.6 µM. 6,7-Dichloroquinoline-5,8-dione has the potential for the research of cancer.
    6,7-Dichloroquinoline-5,8-dione
  • HY-171615
    (4-Phenylphenoxy)phosphonic acid
    		Inhibitor 99.70%
    (4-Phenylphenoxy) phosphonic acid is a protein tyrosine phosphatase (PTP) inhibitor (KM: 86 μM). (4-Phenylphenoxy) phosphonic acid can be used in tuberculosis research.
    (4-Phenylphenoxy)phosphonic acid
  • HY-114460
    SHP2-IN-1
    		Inhibitor ≥99.0%
    SHP2-IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC50 of 3 nM.
    SHP2-IN-1
  • HY-132901
    IACS-15414
    		Inhibitor 99.39%
    IACS-15414 is a potent and orally bioavailable SHP2 inhibitor with an IC50 value of 122 nM.
    IACS-15414
  • HY-101047R
    D-erythro-Sphingosine (Standard)
    		Activator
    D-erythro-Sphingosine (Standard) is the analytical standard of D-erythro-Sphingosine. This product is intended for research and analytical applications. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].
    D-erythro-Sphingosine (Standard)
  • HY-114453
    SHP389
    		Inhibitor 98.03%
    SHP389 is an allosteric SHP2 inhibitor, with an IC50 of 36 nM for both SHP2 and p-ERK.
    SHP389
  • HY-111489A
    LMPTP inhibitor 1 hydrochloride
    		Inhibitor
    LMPTP inhibitor 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
    LMPTP inhibitor 1 hydrochloride
  • HY-P11336A
    Oscillamide C TFA
    		Inhibitor
    Oscillamide C TFA (Compound 2), a ureido-containing cyclic peptide, is a Protein phosphatase 1 (PP1) and Protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.90 and 1.33 μM for PP1 and PP2A, respectively. Oscillamide C TFA can be isolated from the cyanobacteria Planktothrix agardhii and P. rubescens. Oscillamide C TFA can be used for cancers research.
    Oscillamide C TFA
  • HY-160550
    DPM-1003
    		Inhibitor
    DPM-1003 is a PTP1B conformational inhibitor that targets the non-catalytic, disordered segment at the C-terminus of the PTP1B protein, showing improvement in lung inflammation in mice.
    DPM-1003
  • HY-173084
    BRD6257
    		Inhibitor
    BRD6257 is an orally active inhibitor for protein phosphatase, Mg2+/Mn2+ dependent 1D PPM1D with an IC50 of 5 nM. BRD6257 activates p53 signaling pathway with an EC50 of 51 nM, increases the p21 expression, inhibits the proliferation of cancer cell MOLM13 (IC50=2.8 μM). BRD6257 exhibits good metabolic stability in human and rat liver microsomes.
    BRD6257
  • HY-106702
    Fostriecin sodium
    		Inhibitor
    Fostriecin (sodium) (compound 1, CI-920) is an antibiotic with a cytotoxic activity. Fostriecin (sodium) is also an inhibitor of protein phosphatase including PP4 (IC50= 3 nM)and PP2 (IC50=1.5 nM).
    Fostriecin sodium
  • HY-P10168
    11R-CaN-CON
    		Control
    11R-CaN-CON is a control inactive peptide and can be used as a negative control for 11R-CaN-AID (HY-P10167).
    11R-CaN-CON
  • HY-112776
    BN82002
    		Inhibitor
    BN82002 is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 µM, respectively. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase.
    BN82002
  • HY-B0307R
    Idoxuridine (Standard)
    		Inhibitor
    Idoxuridine (Standard) is the analytical standard of Idoxuridine. This product is intended for research and analytical applications. Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM. Idoxuridine shows anti-orthopoxvirus activity.
    Idoxuridine (Standard)
  • HY-W141781
    Cysteamine S-phosphate sodium
    Cysteamine S-phosphate (Cystaphos) sodium can be hydroIyzed to Cysteamine by human alkaline phosphatases. Cysteamine is an orally active agent for the research of nephropathic cystinosis and an antioxidant.
    Cysteamine S-phosphate sodium
  • HY-P10889
    CNI103
    		Inhibitor 99.56%
    CNI103 is a highly potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. CNI103 selectively blocks the interaction between calcineurin and NFATc3 (KD=16 nM), thereby preventing NFATc3 activation in vitro and in vivo. CNI103 can be used to study acute respiratory distress syndrome (ARDS) and other inflammatory diseases.
    CNI103
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity