Phosphatase
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
All Product Categories
-
Phosphatase Inhibitors
(509)
View all products
-
Phosphatase Agonists
(4)
View all products
-
Phosphatase Antagonists
(4)
View all products
-
Phosphatase Activators
(74)
View all products
-
Phosphatase Modulators
(7)
View all products
-
Phosphatase Chemical
(1)
View all products
-
Phosphatase Inducers
(2)
View all products
-
Phosphatase Degraders
(7)
View all products
-
Phosphatase Controls
(3)
View all products
-
Phosphatase Substrates
(7)
View all products
-
Phosphatase Ligands
(11)
View all products
-
Phosphatase Proteins
(66)
View all products
-
Phosphatase Related Products (719)
Related Products (719)
-
Recombinant Proteins (66)
-
Antibodies (40)
-
Related Compound Screening Libraries (1)
-
Diethyl phthalate-d4
0 ImagesDiethyl phthalate-d4 is the d4 labeled Diethyl phthalate (HY-Y0284). Diethyl phthalate is an orally active plasticizer and detergent base. Diethyl phthalate increases the activities of ACP, ALP, SDH, and ALT in liver, muscle, or both tissues. Diethyl phthalate induces dose-dependent mortality and sluggish behavior in freshwater fish. Diethyl phthalate may induce male reproductive toxicity. Diethyl phthalate is added to plastic polymers to help maintain their flexibility.
-
Guaiacin
0 ImagesGuaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation.
-
P5SA-2
0 ImagesP5SA-2 is a selective allosteric activator of PPP5C. P5SA-2 exerts its effects by modulating the phosphatase domain of PPP5C and can increase PPP5C activity by 3.2-fold at 100 μM with an apparent affinity constant of 7.8 μM. P5SA-2 can be used in cancer and Alzheimer's disease research.
-
(R)-GSK 2830371
0 Images(R)-GSK 2830371 is the R-enantiomer of GSK 2830371 (HY-15832). GSK 2830371 is a highly selective Wip1 phosphatase inhibitor with IC50 of 6 nM.
-
PRL-3 Inhibitor 2
0 ImagesPRL-3 Inhibitor 2 (compound 2) is a potent PRL-3 inhibitor with an IC50 value of 28.1 µM.
-
SCP1-IN-1
0 ImagesSCP1-IN-1 is a Small CTD Phosphatase 1 (SCP1) inhibitor with a human IC50 of 10 μM. SCP1-IN-1 inactivates SCP1, promotes REST transcription factor degradation, and reduces REST transcriptional activity. SCP1-IN-1 can be used for the research of glioblastoma multiforme.
-
Hydroxyethylthio Vitamine K3
0 ImagesCat. No.: HY-W024644CAS No.: 59147-84-1Hydroxyethylthio Vitamin K3 is a Cdc25 phosphatase inhibitor, with IC50 values of 4.56 μM and 23.63 μM for Cdc25A and Cdc25B, respectively. Hydroxyethylthio Vitamin K3 can be used in tumor research.
-
L-690330 hydrate
0 ImagesL-690330 hydrate is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 hydrate exhibits 10-fold more sensitive than mouse and rat IMPase.
-
iGePhos1
0 ImagesCat. No.: HY-161408APurity: 98.54%iGePhos1 is an inactive GePhos1 (HY-161408) epimer used as a nonbinding negative control. iGephos1 lacks the phosphatase recruiting possibility.
-
Tos-Gly-Pro-Lys-pNA
0 ImagesTos-Gly-Pro-Lys-pNA is a substrate for the serine protease ALP and can be used to measure the activity of this enzyme.
-
EWP 815
0 ImagesEWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4)P2 phosphatase and Ins(1,4,5)P3 5-phosphatase. EWP 815 also inhibits enzyme dopamine β-hydroxylase activity.
-
Dioctyl phthalate
0 ImagesSynonyms: DNOP; Di-n-octyl phthalate; Phthalic acid dioctyl esterDioctyl phthalate (DNOP) is a plasticizer. Dioctyl phthalate increases the activities of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in the liver, as well as the levels of creatinine and urea in the kidney. Exposure to Dioctyl phthalate disrupts the homeostasis of the intestinal microbial community, increases the abundance of pathogenic bacteria, and reduces the abundance of beneficial bacteria such as Lactobacillus. Dioctyl phthalate induces significant and dose-dependent inflammatory responses in the liver, spleen and kidney of mice.
-
Cassiaside B2
0 ImagesCassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist...
-
Dipropyl phthalate
0 ImagesDipropyl phthalate is an immunomodulator. Dipropyl phthalate alters the activities of acid phosphatase, phenoloxidase and superoxide dismutase, increases the activity of β-glucuronidase in a dose-dependent manner, and elevates the mRNA level of hemocyanin in shrimp. Dipropyl phthalate activates the FoxO signaling pathway, interferes with cell proliferation and apoptosis, downregulates chondrocyte-related genes, and induces craniofacial cartilage developmental malformations in zebrafish embryos. Dipropyl phthalate can be used in studies related to Aeromonas veronii infection and micrognathia syndrome.
-
N-Lauryldiethanolamine
0 ImagesN-Lauryldiethanolamine is an antistatic agent with a strong inhibitory effect on cell growth at 30 μM, showing some lysosomotropic behavior. N-Lauryldiethanolamine is toxic at a concentration of ≥10 μM in the osteogenesis inhibition assay.
-
Ethyl gentisate
0 ImagesEthyl gentisate (Ethyl 2,5-dihydroxybenzoate) is a dual modulator for cell differentiation, that enhances the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and alkaline phosphatase activity, inhibits RANKL-activated osteoclastogenesis in RAW264.7 cells, and balances the bone remodeling process.
-
(4-Phenylphenoxy)phosphonic acid
0 Images(4-Phenylphenoxy) phosphonic acid is a protein tyrosine phosphatase (PTP) inhibitor (KM: 86 μM). (4-Phenylphenoxy) phosphonic acid can be used in tuberculosis research.
-
SHP2-IN-1
0 ImagesCat. No.: HY-114460CAS No.: 1801764-90-8SHP2-IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC50 of 3 nM.
