Cassiaside B2

Cat. No.: HY-N8200 Purity: 99.68%: Data Sheet
COA

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Handling Instructions
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Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist...

For research use only. We do not sell to patients.

Cassiaside B2 Chemical Structure

CAS No. : 218155-40-9

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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•Related Screening Libraries:

•Related Small Molecules:

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View All Monoamine Oxidase Isoform Specific Products:

View All Isoforms

MAO-A MAO-B

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist^[1]^[2].^[3]..

IC₅₀ & Target

5-HT_2C Receptor

Molecular Weight

920.82

Formula

C₃₉H₅₂O₂₅

CAS No.

218155-40-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=C(C(C=C(O2)C)=O)C2=CC3=C1C(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)O)=CC(OC)=C3

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (54.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0860 mL	5.4299 mL	10.8599 mL
5 mM	0.2172 mL	1.0860 mL	2.1720 mL
10 mM	0.1086 mL	0.5430 mL	1.0860 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (255 KB) HNMR (332 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Pradeep Paudel, et al. Rubrofusarin as a Dual Protein Tyrosine Phosphate 1B and Human Monoamine Oxidase-A Inhibitor: An in Vitro and in Silico Study. ACS Omega. 2019 Jul 3;4(7):11621-11630. [Content Brief]

[2]. S Kitanaka, et al. Antiallergic agent from natural sources. Structures and inhibitory effect of histamine release of naphthopyrone glycosides from seeds of Cassia obtusifolia L. Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1650-2. [Content Brief]

[3]. Heidi Yuen, et al. Mechanisms of Action of Cassiae Semen for Weight Management: A Computational Molecular Docking Study of Serotonin Receptor 5-HT2C. Int J Mol Sci. 2020 Feb 16;21(4):1326. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0860 mL	5.4299 mL	10.8599 mL	27.1497 mL
	5 mM	0.2172 mL	1.0860 mL	2.1720 mL	5.4299 mL
	10 mM	0.1086 mL	0.5430 mL	1.0860 mL	2.7150 mL
	15 mM	0.0724 mL	0.3620 mL	0.7240 mL	1.8100 mL
	20 mM	0.0543 mL	0.2715 mL	0.5430 mL	1.3575 mL
	25 mM	0.0434 mL	0.2172 mL	0.4344 mL	1.0860 mL
	30 mM	0.0362 mL	0.1810 mL	0.3620 mL	0.9050 mL
	40 mM	0.0271 mL	0.1357 mL	0.2715 mL	0.6787 mL
	50 mM	0.0217 mL	0.1086 mL	0.2172 mL	0.5430 mL

Cassiaside B2 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cassiaside B2218155-40-9Cassiaside B 2Cassiaside B-2PhosphataseMonoamine Oxidase5-HT ReceptorMAOSerotonin Receptor5-hydroxytryptamine ReceptorPTP1BhMAO-AantiallergicInhibitorinhibitorinhibit

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