1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. SHP389

SHP389 

Cat. No.: HY-114453
Handling Instructions

SHP389 is an allosteric SHP2 inhibitor, with an IC50 of 36 nM for both SHP2 and p-ERK.

For research use only. We do not sell to patients.

SHP389 Chemical Structure

SHP389 Chemical Structure

CAS No. : 2235394-90-6

Size Price Stock Quantity
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SHP389 is an allosteric SHP2 inhibitor, with an IC50 of 36 nM for both SHP2 and p-ERK[1].

IC50 & Target

IC50: 36 nM (SHP2 and p-ERK)[1].

In Vivo

SHP389 modulates MAPK signaling in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

484.98

Formula

C₂₃H₂₉ClN₈O₂

CAS No.
SMILES

O=C1C2=C(C3=C(Cl)C(NC4CC4)=NC=C3)NN=C2N=C(N(CC5)CCC65[[email protected]](N)[[email protected]](C)OC6)N1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0619 mL 10.3097 mL 20.6194 mL
5 mM 0.4124 mL 2.0619 mL 4.1239 mL
10 mM 0.2062 mL 1.0310 mL 2.0619 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (10.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (10.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SHP389SHP 389SHP-389PhosphataseInhibitorinhibitorinhibit

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Product Name:
SHP389
Cat. No.:
HY-114453
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