Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Tyrosinase Related Products (301)
Antibodies (9)

By Effects:	Inhibitors (259) Degrader (1) Substrates (6) Antagonist (1) Activators (10) Modulator (1) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N0136S

Taxifolin-d₃	Inhibitor
Taxifolin-d₃ is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-171155

CLIP1-LTK fusion protein regulator-1	Inhibitor
CLIP1-LTK fusion protein regulator-1 is a 7-azaindol-6-amine class CLIP1-LTK fusion protein regulator and CLIP1-LTK fusion protein receptor inhibitor. CLIP1-LTK fusion protein regulator-1 suppresses abnormal proliferation of CLIP1-LTK-dependent cells.CLIP1-LTK fusion protein regulator-1 can be used for the research of non-small cell lung cancer.

HY-W013636AG

2-Ketoglutaric acid Sodium (GMP)	Inhibitor
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) Sodium (GMP) is 2-Ketoglutaric acid Sodium (HY-W013636A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 2-Ketoglutaric acid Sodium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

HY-145111

TNK2-IN-1	Inhibitor
TNK2-IN-1 is a TNK2 inhibitor. TNK2-IN-1 has an IC₅₀ of 224 nM for TNK2. TNK2-IN-1 can be used for the research of cancer.

HY-168436

Tyrosinase-IN-40	Inhibitor
Tyrosinase-IN-40 (Compound 9r) is a competitive-type tyrosinase inhibitor, with an IC₅₀ value of 17.02 µM, a K_i value of 14.87 µM. Tyrosinase-IN-40 displays antioxidant activity. Tyrosinase-IN-40 can be used in melanin-related studies.

HY-N7929R

5-Feruloylquinic acid (Standard)	Inhibitor
5-Feruloylquinic acid (Standard) is the analytical standard of 5-Feruloylquinic acid (HY-N7929). This product is intended for research and analytical applications. 5-Feruloylquinic acid (5-FQA) is a hydroxycinnamic acid derivative. 5-Feruloylquinic acid can be isolated from green coffee beans. 5-Feruloylquinic acid inhibits tyrosinase activity. 5-Feruloylquinic acid has antioxidant properties. 5-Feruloylquinic acid has anticancer activity against lymphoma, oral epidermal cancer, and breast cancer.

HY-178055

Tyrosinase-IN-44	Inhibitor
Tyrosinase-IN-44 (Compound 3) is a Tyrosinase inhibitor with IC₅₀s of 0.47  and 0.53 μM for monophenolase and diphenolase, respectively. Tyrosinase-IN-44 has superior glutathione peroxidase-like catalytic and DPPH radical scavenging activity. Tyrosinase-IN-44 has potent antibrowning activity in banana and apple juices by directly inhibiting polyphenol oxidase (PPO) and offering antioxidant activity. Tyrosinase-IN-44 can be used for redox regulation and food preservation.

HY-163326

Tyrosinase-IN-25	Inhibitor
Tyrosinase-IN-25 (compound 1l) is an inhibitor of tyrosinase and melanin biosynthesis in human melanoma cells.

HY-151979

Tyrosinase-IN-8	Inhibitor
Tyrosinase-IN-8 is a potent tyrosinase inhibitor with an IC₅₀ value of 1.6 µM. Tyrosinase-IN-8 inhibits cell growth with low cytotoxicity.

HY-121374

Cardanol diene	Inhibitor
Cardanol diene is a phenol found in cashew nut shell liquid that inhibits tyrosinase with an IC₅₀ value of 52.5 μM in vitro.1 Cardanol diene is also used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.

HY-N2962

Broussonin C	Inhibitor
Broussonin C is a competitive inhibitor of Tyrosinase that can be isolated from Broussonetia kazinoki. Broussonin C inhibits monophenolase and diphenolase with IC₅₀s of 0.43 and 0.57 μM, respectively.

HY-155247

Tyrosinase-IN-14	Inducer
Tyrosinase-IN-14 (compound 7m) is a tyrosinase inhibitor that reduces the catalytic activity of tyrosinase by changing its secondary structure. Tyrosinase-IN-14 has low cytotoxicity and anti-browning activity in fruits. Tyrosinase-IN-14 effectively inhibits banana browning during storage.

HY-158235

Tyrosinase-IN-27	Inhibitor
Tyrosinase-IN-27 (compound 6f) is a tyrosinase (TYR) inhibitor (IC₅₀: 0.88 μM) that statically quenches TYR. Tyrosinase-IN-27 increases the hydrophobicity of the enzyme microenvironment by binding to TYR, reducing the content of α-helices in the enzyme and changing its secondary structure. Tyrosinase-IN-27 can be used in the food industry to effectively inhibit the browning of lotus root slices..

HY-N18197

Norkurarinol	Inhibitor
Norkurarinol is a prenylated flavonoid. Norkurarinol can be isolated from Sophora flavescens. Norkurarinol potently inhibits mushroom Tyrosinase DOPA oxidase activity with an IC₅₀ of 2.1 μM. Norkurarinol inhibits poly(I:C)-induced NF-κB/AP-1 activation. Norkurarinol inhibits pro-inflammatory cytokines (TNF-α, IL-6). Norkurarinol inhibits phosphorylation of p38, JNK, and ERK1/2. Norkurarinol increases phosphorylation of IRF3. Norkurarinol has antiviral activity against Rotavirus KJ56-1

HY-Y0444S

D-Tyrosine-d₂	Inhibitor
D-Tyrosine-d₂ is the deuterium labeled D-Tyrosine (HY-Y0444). D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.

HY-111289

Tec-IN-14	Inhibitor
Tec-IN-14 blocks the interaction between Tec kinase and FGF2 with an IC₅₀ of 7.0 μM. Tec-IN-14 inhibits the non-classical secretion of FGF2 in cells. Tec-IN-14 suppresses the tyrosine phosphorylation of FGF2 in a cellular environment. Tec-IN-14 is applicable to research related to cancer.

HY-139857

Piceid 6″-O-azelaic acid ester	Inhibitor
Piceid 6″-O-azelaic acid ester shows high intracellular tyrosinase inhibitory and depigmentating activities.

HY-N11521

7-Methoxy obtusifolin	Inhibitor
7-Methoxy obtusifolin (Compound 4) is a competitive tyrosinase inhibitor with an IC₅₀ of 7.0 μM.

HY-162909

Tyrosinase-IN-38	Inhibitor
Tyrosinase-IN-38 (compound 6b) is a competitive Tyrosinase inhibitor with IC₅₀ value of 25.82 μM. Tyrosinase-IN-38 has antioxidant activity.

HY-N17917

3-Feruloyl-4',6'-diacetyl sucrose	Inhibitor
3-Feruloyl-4',6'-diacetyl sucrose is a feruloyl sucrose ester that can be found in the roots of Oryza sativa.

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Tyrosinase

Tyrosinase

Tyrosinase Related Products (301)

Antibodies (9)

Tyrosinase Related Products (301):