Tec-IN-14
Tec-IN-14 blocks the interaction between Tec kinase and FGF2 with an IC50 of 7.0 μM. Tec-IN-14 inhibits the non-classical secretion of FGF2 in cells. Tec-IN-14 suppresses the tyrosine phosphorylation of FGF2 in a cellular environment. Tec-IN-14 is applicable to research related to cancer.
For research use only. We do not sell to patients.
- CAS No.: 852838-07-4
- Formula: C18H16BrN3O4
- Molecular Weight:418.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tec-IN-14 (compound 14) (50 μM) inhibits tyrosine phosphorylation of FGF2 in FGF2-GFP-expressing CHO cells[1].
Tec-IN-14 (10-50 μM; 40 h) inhibits the non-canonical secretion of FGF2 in CHO cells in a dose-dependent manner[1].
Tec-IN-14 (10-50 μM; 72 h) exerts no significant pleiotropic effects on the viability or proliferation of CHO cells, but only causes a slight reduction in proliferation rate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO cells with Doxycycline (HY-N0565)-inducible FGF2-GFP expression
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Concentration:10, 25, and 50 μM
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Incubation Time:40 h (including 24 h pre-incubation and 16 h doxycycline-induced expression)
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Result:Inhibited FGF2-GFP secretion to cell surfaces in a dose-dependent manner.
Chemical Information
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CAS No. 852838-07-4
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Molecular Weight 418.25
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Formula C18H16BrN3O4
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SMILES
O=C(OCC=1N=C2C=CC(Br)=CN2C(=O)C1)C=3NC(=C(C(=O)C)C3C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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