2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14735
    Dotriacolide
    		Inhibitor
    Dotriacolide is a β-actamase inhibitor. Dotriacolide has significant inhibitory activities against both penicillinase and cephalosporinase with ID50 values of 0.61 μg/mL and 0.15 μg/mL, respectively. Dotriacolide is promising for research of infectious diseases.
    Dotriacolide
  • HY-W151758
    2'-Hydroxybiphenyl-3-carboxylic acid
    		Inhibitor 98.46%
    2'-Hydroxybiphenyl-3-carboxylic acid is a β-lactamase oxa-48 inhibitor (IC50 = 50 µM; Kd = 1750 µM) .
    2'-Hydroxybiphenyl-3-carboxylic acid
  • HY-120366
    WCK-5153
    WCK-5153 is a Penicillin-Binding Protein 2 (PBP2) inhibitor with an IC50 of 0.14 μg/ml (for P. aeruginosa PBP2) and acts as a β-lactam enhancer against Pseudomonas aeruginosa. WCK-5153 can be used in studies of multidrug-resistant (MDR) pathogens.
    WCK-5153
  • HY-B0368B
    D-Captopril
    		Inhibitor
    D-Captopril is a NDM-1 inhibitor and a competitive BlaB inhibitor, with an IC50 value of 21.8 µM against NDM-1 and a Ki of 70-100 µM against BlaB. D-Captopril synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-expressing bacteria. D-Captopril binds to BcII via its thiolate sulfur atom and carboxylate group, altering metal ion occupancy and modulating Cd2+ binding affinity. D-Captopril can be used in the research of neonatal meningitis, sepsis and bacterial infections.
    D-Captopril
  • HY-N14919
    Olivanic acid
    Olivanic acid is a β -lactam antibiotic. Olivanic acid has the effect of anti -Gram-positive bacteria and anti-Gram-negative bacteria. Olivanic acid inhibits β-lactamase.
    Olivanic acid
  • HY-B1300B
    Cefonicid monosodium
    		Inhibitor
    Cefonicid monosodium is a long-acting cephalosporin antibiotic. Cefonicid monosodium also acts as a noncompetitive class I β-lactamase inhibitor with a Ki value of 0.8 μM. Cefonicid monosodium exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid monosodium can be used for research on infections.
    Cefonicid monosodium
  • HY-16752S1
    Relebactam-d9
    		Inhibitor
    Relebactam-d9 (MK-7655-d9) is deuterium labeled Relebactam. Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity.
    Relebactam-d<sub>9</sub>
  • HY-A0088S
    Cefotaxime-d3 sodium
    		Inhibitor
    Cefotaxime-d3 (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.
    Cefotaxime-d<sub>3</sub> sodium
  • HY-N13977
    Carpetimycin A
    		Inhibitor
    Carpetimycin A has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin A has a strong inhibitory effect on β-lactamase.
    Carpetimycin A
  • HY-108062R
    BLI-489 (Standard)
    		Inhibitor
    BLI-489 (Standard) is the analytical standard of BLI-489 (HY-108062). This product is intended for research and analytical applications. BLI-489 is a beta-lactamase inhibitor. BLI-489 combined with Piperacillin (HY-B1923) inhibits infection caused by class A (including ultra-broad spectrum β-lactamase), Class C (AmpC) and Class D β-lactamase expressing pathogens.
    BLI-489 (Standard)
  • HY-N13979
    Carpetimycin C
    		Inhibitor
    Carpetimycin C has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin C has a strong inhibitory effect on β-lactamase.
    Carpetimycin C
  • HY-13428R
    Tubacin (Standard)
    		Inhibitor
    Tubacin (Standard) is the analytical standard of Tubacin. This product is intended for research and analytical applications. Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2).
    Tubacin (Standard)
  • HY-175724
    MBL-IN-6
    		Inhibitor
    MBL-IN-6 (Compound 6d) is a Metallo-β-lactamase (MBL) inhibitor with Kis of 2.6 and 0.08 μM for NDM-1 and VIM-2, respectively. MBL-IN-6 has a synergistic activities with Imipenem (HY-B1369A) on MBL-producing clinical isolates (such as E. coli SI-M001, K. pneumonia T2301 and S. marcescens SI-1591) with MICs of 2-64 μg/mL. MBL-IN-6 does not have off-target effects without ACE-1 inhibition activity. MBL-IN-6 can be used for antimicrobial resistance research.
    MBL-IN-6
  • HY-16752A
    Relebactam sodium
    		Inhibitor
    Relebactam sodium (MK-7655 sodium) is a potent and selective β-lactamase inhibitor with the activity of delaying the development of bacterial resistance to antibiotics. Relebactam sodium can bind to a variety of β-lactamases, thereby improving the efficacy of β-lactam antibiotics. Relebactam sodium shows good application potential in inhibiting complicated bacterial infections.
    Relebactam sodium
  • HY-17452B
    Cefditoren Pivoxil hydrochloride
    		Inhibitor
    Cefditoren Pivoxil (ME 1207) hydrochloride is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
    Cefditoren Pivoxil hydrochloride
  • HY-183512
    Ceftazidime sodium
    Ceftazidime sodium (GR20263 sodium), an Antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime sodium is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.
    Ceftazidime sodium
  • HY-13573R
    Biapenem (Standard)
    		Inhibitor
    Biapenem (Standard) is the analytical standard of Biapenem. This product is intended for research and analytical applications. Biapenem (CLI 86815; L 627; LJC 10627) a parenteral carbapenem antibacterial agent with a broad spectrum.
    Biapenem (Standard)
  • HY-158977
    β-Lactamase-IN-9
    		Inhibitor
    β-Lactamase-IN-9 (compound 2) is a β-lactamase inhibitor that can restore the sensitivity of pathogens to β-lactam antibiotics.
    β-Lactamase-IN-9
  • HY-14879D
    ent-Avibactam sodium
    Ent-Avibactam sodium (AVE1330A) is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), ent-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC50 value of ent-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes.
    ent-Avibactam sodium
  • HY-110061
    (2R,4R,6S)-Tubacin
    		Control
    (2R,4R,6S)-Tubacin is the 2R,4R,6S enantiomer of Tubacin (HY-13428). Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2).
    (2R,4R,6S)-Tubacin
Beta-lactamase Isoform Comparison

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