Cefonicid monosodium 

Cefonicid monosodium is a long-acting cephalosporin antibiotic. Cefonicid monosodium also acts as a noncompetitive class I β-lactamase inhibitor with a K_i value of 0.8 μM. Cefonicid monosodium exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid monosodium can be used for research on infections^[1][2][3][4].

Cefonicid (25-200 mg/L; 3-6 days) monosodium dose-dependently inhibits the proliferation of human PBMCs stimulated by FLU, XENO, ALLO, and PHA (HY-N7038)^[1].
Cefonicid (0-200 mg/L; 7 days) monosodium dose-dependently inhibits IL-2 production by human PBMC stimulated with FLU, XENO and ALLO^[1].
Cefonicid (0-24 h) monosodium exhibits concentration-dependent bactericidal activity against Klebsiella pneumoniae strain 2603 in vitro, with an MIC of 0.25 mg/L^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefonicid (15 mg/kg; i.p.; 2 doses) monosodium significantly reduces the pulmonary bacterial load in guinea pigs infected with K. pneumoniae^[3].
Cefonicid (40 mg/kg; single dose) monosodium exhibits excellent protective effects against S. aureus, E. coli, P. mirabilis, and K. pneumoniae infections in mice^[4].
Cefonicid monosodium exerts excellent preventive protective effects against surgical wound infections in mice, with an ED₅₀ value of ≤2.1 mg/kg against Gram-negative bacilli and an ED₅₀ value ranging from 3.7 to 8.7 mg/kg against S. aureus^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

564.55

C₁₈H₁₇N₆NaO₈S₃

71420-79-6

O=C(O)C(N12)=C(CSC3=NN=NN3CS(=O)(O[Na])=O)CS[C@]2([H])[C@H](NC([C@H](O)C4=CC=CC=C4)=O)C1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Villa ML, et al. Interference of cephalosporins with immune response: effects of cefonicid on human T-helper cells. Int J Immunopharmacol. 1991;13(8):1099-1107.  [Content Brief]

  [2]. MEHTA R J, et al. Cefonicid: a stable β-lactamase inhibitor. The Journal of Antibiotics, 1981, 34(2): 202-205.

  [3]. Drago L, et al. Evaluation of antibacterial activity of cefodizime, ceftriaxone and cefonicid in Klebsiella pneumoniae-infected guinea pigs. Clinical microbiology and infection, 1999, 5(6): 371-373.

  [4]. Saltiel E, et al. Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1986;32(3):222-259.  [Content Brief]