71420-79-6
Chemical Structure
Cefonicid monosodium
- CAS No.: 71420-79-6
- Formula:C18H17N6NaO8S3
- Molecular Weight:564.55
InChIKey: WZTUULPOBSTZKR-CFOLLTDRSA-M
SMILES: O=C(O)C(N12)=C(CSC3=NN=NN3CS(=O)(O[Na])=O)CS[C@]2([H])[C@H](NC([C@H](O)C4=CC=CC=C4)=O)C1=O
Biological Activity: Cefonicid monosodium is a long-acting cephalosporin antibiotic. Cefonicid monosodium is also a non-competitive type I β-lactamase with a Ki value of 0.8 μM. Cefonicid monosodium exhibits broad-spectrum antibacterial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid monosodium binds PBP1a, PBP1b, and PBP3, inhibiting peptidoglycan synthesis and leading to filamentation and lysis. Cefonicid monosodium can be used for research on infections[1][2][3][4][5].
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Cefonicid monosodium | Cefonicid monosodium is a long-acting cephalosporin antibiotic. Cefonicid monosodium is also a non-competitive type I β-lactamase with a Ki value of 0.8 μM. Cefonicid monosodium exhibits broad-spectrum antibacterial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid monosodium binds PBP1a, PBP1b, and PBP3, inhibiting peptidoglycan synthesis and leading to filamentation and lysis. Cefonicid monosodium can be used for research on infections. | |||||||||||||||||||||
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References
- [1]. Villa ML, et al. Interference of cephalosporins with immune response: effects of cefonicid on human T-helper cells. Int J Immunopharmacol. 1991;13(8):1099-1107. [Content Brief]
- [2]. MEHTA R J, et al. Cefonicid: a stable β-lactamase inhibitor. The Journal of Antibiotics, 1981, 34(2): 202-205.
- [3]. Drago L, et al. Evaluation of antibacterial activity of cefodizime, ceftriaxone and cefonicid in Klebsiella pneumoniae-infected guinea pigs. Clinical microbiology and infection, 1999, 5(6): 371-373.
- [4]. Saltiel E, et al. Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1986;32(3):222-259. [Content Brief]
- [5]. Rake JB, et al. Affinity of cefonicid, a long-acting cephalosporin, for the penicillin-binding proteins of Escherichia coli K-12. The Journal of antibiotics. 1984 May;37(5):572-6. [Content Brief]
