Cefonicid sodium
Based on 1 Customer Validation
Cefonicid sodium is a long-acting cephalosporin antibiotic. Cefonicid sodium is also a non-competitive type I β-lactamase with a Ki value of 0.8 μM. Cefonicid sodium exhibits broad-spectrum antibacterial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid sodium binds PBP1a, PBP1b, and PBP3, inhibiting peptidoglycan synthesis and leading to filamentation and lysis. Cefonicid sodium can be used for research on infections.
For research use only. We do not sell to patients.
- Purity : 95.0%
- CAS No.: 61270-78-8
- Formula: C18H16N6Na2O8S3
- Molecular Weight:586.53
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
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PBP1a |
PBP1b |
PBP3 |
In Vitro
Cefonicid (0-24 h) sodium exhibits concentration-dependent bactericidal activity against Klebsiella pneumoniae strain 2603 in vitro, with an MIC of 0.25 mg/L[3].
Cefonicid sodium binds to PBPs of E. coli K-12 KN-126, with the highest affinity for PBP 1a, followed by PBP 3, and does not significantly bind PBP 5 or 6[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Cefonicid (40 mg/kg; single dose) sodium exhibits excellent protective efficacy against S. aureus, E. coli, P. mirabilis, and K. pneumoniae infections in mice[4].
Cefonicid sodium has excellent prophylactic protective efficacy against surgical wound infections in mice, with an ED50 value of ≤2.1 mg/kg against Gram-negative bacilli and an ED50 value of 3.7 to 8.7 mg/kg against S. aureus[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hartley (female, 220-250 g)[3]
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Dosage:15 mg/kg
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Administration:i.p.; 2 doses (immediately and 24 hours post-challenge)
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Result:Showed similar lung bacterial counts to infected untreated controls at 0 and 1 hour post-challenge.
Reduced lung bacterial counts significantly compared to infected untreated controls starting at 6 hours post-challenge, with significant reductions also seen at 24 and 48 hours post-challenge.
Chemical Information
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CAS No. 61270-78-8
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Appearance Solid
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Molecular Weight 586.53
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Formula C18H16N6Na2O8S3
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Color White to off-white
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SMILES
O=C(C(N12)=C(CSC3=NN=NN3CS(=O)(O[Na])=O)CS[C@]2([H])[C@H](NC([C@H](O)C4=CC=CC=C4)=O)C1=O)O[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 116.67 mg/mL (198.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (170.49 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (292 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Villa ML, et al. Interference of cephalosporins with immune response: effects of cefonicid on human T-helper cells. Int J Immunopharmacol. 1991;13(8):1099-1107. [Content Brief]
[4]. Saltiel E, et al. Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1986;32(3):222-259. [Content Brief]
[5]. Rake JB, et al. Affinity of cefonicid, a long-acting cephalosporin, for the penicillin-binding proteins of Escherichia coli K-12. The Journal of antibiotics. 1984 May;37(5):572-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 1.7049 mL | 8.5247 mL | 17.0494 mL | 42.6236 mL |
| 5 mM | 0.3410 mL | 1.7049 mL | 3.4099 mL | 8.5247 mL | |
| 10 mM | 0.1705 mL | 0.8525 mL | 1.7049 mL | 4.2624 mL | |
| 15 mM | 0.1137 mL | 0.5683 mL | 1.1366 mL | 2.8416 mL | |
| 20 mM | 0.0852 mL | 0.4262 mL | 0.8525 mL | 2.1312 mL | |
| 25 mM | 0.0682 mL | 0.3410 mL | 0.6820 mL | 1.7049 mL | |
| 30 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4208 mL | |
| 40 mM | 0.0426 mL | 0.2131 mL | 0.4262 mL | 1.0656 mL | |
| 50 mM | 0.0341 mL | 0.1705 mL | 0.3410 mL | 0.8525 mL | |
| 60 mM | 0.0284 mL | 0.1421 mL | 0.2842 mL | 0.7104 mL | |
| 80 mM | 0.0213 mL | 0.1066 mL | 0.2131 mL | 0.5328 mL | |
| 100 mM | 0.0170 mL | 0.0852 mL | 0.1705 mL | 0.4262 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cefonicid sodium Related Classifications
HY-B1300 Related Classifications
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Keywords
- Cefonicid
- 61270-78-8
- Bacterial
- Antibiotic
- Beta-lactamase
- Interleukin Related
- Penicillin-binding protein (PBP)
- β-lactamase
- IL
- Bacteroides fragilis
- CD4+ T-helper cells
- Enterobacter cloacae
- Klebsiella pneumoniae
- beta-lactamase
- interleukin-2
- penicillin-binding protein 1a
- penicillin-binding protein 1b
- penicillin-binding protein 3
- peptidoglycan synthesis
- Inhibitor
- inhibitor
- inhibit