Ceftazidime sodium (Synonyms: GR20263 sodium)

Cat. No.: HY-183512: Data Sheet Handling Instructions
FAQs
Technical Support

Ceftazidime sodium (GR20263 sodium), an Antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime sodium is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.

For research use only. We do not sell to patients.

CAS No. : 73547-61-2

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Ceftazidime sodium:

Ceftazidime

Other Forms of Ceftazidime sodium:

Ceftazidime In-stock

42 Publications Citing Use of MCE Ceftazidime sodium

Microbiological Assay

In Vivo Efficacy Study

: Ceftazidime sodium purchased from MedChemExpress. Usage Cited in: Mol Syst Biol. 2025 Jun 30. [Abstract]; Growth and cadaverine production dynamics in E. coli treated with 20 µM of Ceftazidime. Treated cultures show a brief period where the optical density (Absorbance, 595 nm) increases, concurrent with a burst of cadaverine production far above untreated levels. This indicates that this β-lactam antibiotic does not immediately kill the cells but allows for a brief period of growth and stress-induced polyamine production prior to bacterial cell lysis. Lines indicate the mean, and shaded areas the standard deviation of n = 6 biological replicates.

: Ceftazidime sodium purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]; Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.

: Ceftazidime sodium purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575.; Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

: Ceftazidime sodium purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2022 Sep 30;77(10):2803-2808. [Abstract]; In vivo change in log10 cfu/thigh of each isolate treated with saline control, Ceftazidime 2 g IV q8h 2 h infusion HSR, Ceftazidime/Avibactam 2.5 g q8h 2 h infusion HSR or meropenem 2 g q8h 3 h infusion HSR for three P. aeruginosa with inserted GES β-lactamases. (a) PSA 2136, with inserted GES-1 (ESBL). (b) PSA 2137, with inserted GES-5 (carbapenemase). (c) PSA 2138, with inserted GES-15. P values in the boxes represent the results from one-way ANOVA; P values are presented if between-group differences were present. The x-axis describes the treatment HSR [MIC (mg/L), % fT>MIC]. CAZ, Ceftazidime; CAZ-AVI, Ceftazidime/Avibactam; MEM, meropenem.

: Ceftazidime sodium purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858. [Abstract]; The cumulative MIC distributions of Cefepime/Taniborbactam, Ceftazidime/Avibactam and comparator Meropenem for 500 tested isolates. The MICs of cefepime and Cefepime/Taniborbactam shown in the figure were tested by the broth microdilution method. The MICs of Meropenem shown in the figure were tested by the agar dilution method. SS, susceptible to all tested β-lactams. SS-P. aeruginosa, meropenem-susceptible P. aeruginosa. Nine IMP producers included three blaIMP-producing P. aeruginosa.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

View All Isoforms

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

View All Beta-lactamase Isoform Specific Products:

View All Isoforms

Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Ceftazidime (0-8 μg/mL approximately, 24 h) sodium displays antibacterial and anti-biofilm activities against P. aeruginosa strains^[2].
Ceftazidime (0-40 μg/mL approximately, 18-20 h) sodium has inhibitory activities against S. maltophilia isolates^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	P. aeruginosa strains (PAO1, PA1, PA2)
Concentration:	0-8 µg/mL approximately
Incubation Time:	24 h
Result:	Displayed antibacterial and anti-biofilm activities with MIC values of 2-4 µg/mL.

In Vivo

Ceftazidime (2 h infusion of injection, 2 000 mg, every 8 h for 24 h) sodium moderately reduces bacterial density in a murine thigh infection model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Murine thigh infection model^[4]
Dosage:	2000 mg
Administration:	2 h infusion of injection, every 8 h for 24 h.
Result:	Reduced bacterial density against the isogenic NDM (New Delhi metallo-β-lactamase) strain.

Molecular Weight

568.56

Formula

C₂₂H₂₁N₆NaO₇S₂

CAS No.

73547-61-2

SMILES

[O-]C(C1=C(C[N+]2=CC=CC=C2)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC(C)(C)C(O[Na])=O)=O)([H])N1C3=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Richards DM, et al. Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985 Feb;29(2):105-61. [Content Brief]

[2]. Esmat Kamali, et al. In vitro activities of cellulase and ceftazidime, alone and in combination against Pseudomonas aeruginosa biofilms. BMC Microbiol. 2021 Dec 16;21(1):347. [Content Brief]

[3]. Qiuxia Lin, et al. Avibactam potentiated the activity of both ceftazidime and aztreonam against S. maltophilia clinical isolates in vitro. BMC Microbiol. 2021 Feb 22;21(1):60. [Content Brief]

[4]. Shawn H MacVane, et al. Unexpected in vivo activity of ceftazidime alone and in combination with avibactam against New Delhi metallo-β-lactamase-producing Enterobacteriaceae in a murine thigh infection model. Antimicrob Agents Chemother. 2014 Nov;58(11):7007-9. [Content Brief]

Ceftazidime sodium Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceftazidime73547-61-2GR20263GR 20263GR-20263BacterialAntibioticBeta-lactamaseβ-lactamaseBiofilmGramthigh infectionlactamaseinfectionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #