Dengue Virus
DENV
Dengue virus (DENV) belongs to the Flaviviridae family and is a small enveloped virus with a single-stranded positive-sense RNA of about 11kb in length and a granular spherical shape. DENV contains 4 serotypes: DENV serotype 1, DENV-2, DENV-3 and DENV-4. Envelope Protein E, NS3, NS5, etc. are effective targets for DENV inhibitors, which work by blocking viral entry, inhibiting protein processing and replication, and interfering with RNA capping. NS4B inhibitors can also disrupt related effects and inhibit the formation of viral replication complexes.
References:
- [1]. Dengue Virus. Sciencedirect Topic.
- [2]. Chauhan N, et al. Dengue virus: pathogenesis and potential for small molecule inhibitors. Biosci Rep. 2024 Aug 28;44(8):BSR20240134. [Content Brief]
- [3]. Kiemel D, et al. Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation. Nat Commun. 2024 Jul 19;15(1):6080.x [Content Brief]
- [4]. Lee MF, et al. Molecular Mechanisms of Antiviral Agents against Dengue Virus. Viruses. 2023 Mar 8;15(3):705.x [Content Brief]
All Product Categories
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Dengue Virus Related Products (170)
Related Products (170)
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RdRP-IN-11
0 ImagesCat. No.: HY-100730CAS No.: 1884574-15-5RdRP-IN-11 is a non-nucleoside dengue virus RNA-dependent RNA polymerase (RdRp) inhibitor that binds to the palm subdomain of DENV NS5 RdRp, with an IC50 of 23 nM and a Kd of 7 nM. RdRP-IN-11 exhibits antiviral activity against all four dengue serotypes. RdRP-IN-11 can be used for dengue-related research.
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2A/2B Dengue protease substrate
0 ImagesCat. No.: HY-P11420CAS No.: 410532-55-72A/2B Dengue protease substrate (Ac-RTSKKR-pNA) is a peptide substrate for the Dengue NS2B-NS3 protease, with a Ki value of 12 μM. 2A/2B Dengue protease substrate is used in the development of selective peptide-based inhibitors for the Dengue NS2B-NS3 protease.
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MLH40
0 ImagesCat. No.: HY-P10829MLH40 is a peptide inhibitor with activity against Dengue virus (DENV) infection, which is found in the conserved ectodomain region of DENV membrane protein. MLH40 inhibits DENV through its N-terminal loop interaction with DENV envelope protein and altering the dimer conformation.
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ToP-DNJ
0 ImagesCat. No.: HY-125426CAS No.: 1508303-85-2ToP-DNJ is a selective endoplasmic reticulum α-glucosidase II (GluII) inhibitor with an IC50 value of 9.0 μM. ToP-DNJ selectively inhibits the two catalytic reactions of GluII, and exhibits stronger activity in the first step of converting di-glycosylated glycans to mono-glycosylated glycans. ToP-DNJ exhibits anti-DENV activity. ToP-DNJ can be used in studies related to dengue virus infection.
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JMX0254
0 ImagesCat. No.: HY-149467CAS No.: 2375960-04-4JMX0254 is an orally active and potent inhibitor of the dengue virus NS4B protein. JMX0254’s EC50 for DENV-1, DENV-2, and DENV-3 are 0.78 µM, 0.16 µM, and 0.035 µM, respectively. JMX0254 can be used for research on viral infections.
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3'-Deoxy-GTP
0 ImagesCat. No.: HY-134991CAS No.: 55968-37-1Synonyms: 3′-Deoxyguanosine 5′-triphosphate3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate), an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP inhibits DENV NS5 RdRp (IC50: 0.02 μM).
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Pancracine
0 ImagesCat. No.: HY-N20721CAS No.: 21416-14-8Pancracine is an alkaloid. Pancracine upregulates p27, phosphorylated p38 MAPK and phosphorylated p53, while downregulating phosphorylated Akt and phosphorylated Rb. Pancracine induces G1 cell cycle arrest and Apoptosis in cells. Pancracine inhibits the replication of pseudotyped HIV-1 and Dengue virus. Pancracine can be used in research related to lung adenocarcinoma, acute lymphoblastic leukemia, cutaneous epidermoid carcinoma, human immunodeficiency virus infection and dengue virus infection.
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HS-72
0 ImagesCat. No.: HY-117252CAS No.: 1118861-60-1HS-72 is a selective allosteric inducible heat shock protein 70 Hsp70i inhibitor. HS-72 reduces ATP affinity of Hsp70i, elevates caspase 3/7 apoptotic activity, and promotes degradation of Hsp70 client proteins, including HER2 and Akt, and blocks DENV entry by disrupting Hsp70i association with the DENV receptor complex. HS-72 can be used for breast cancer and dengue virus infection research.
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4-Methoxycinnamic acid ethyl ester
0 Images4-Methoxycinnamic acid ethyl ester (Ethyl p-methoxycinnamate) is an orally active natural compound found. 4-Methoxycinnamic acid ethyl ester exerts anti-inflammatory effects by inhibiting cyclooxygenase (COX-1 (IC50 = 1.12 μM) and COX-2 (IC50 = 0.83 μM)), NF-κB (IC50 = 88.7 μM) and cytokine production (TNF-α (IC50 = 96.84 μg/mL) and IL-1β (IC50 = 166.4 μg/mL)). 4-Methoxycinnamic acid ethyl ester inhibits tumor cell proliferation, migration and cancer metabolism and induces apoptosis.4-Methoxycinnamic acid ethyl ester inhibits VEGF expression, thereby inhibiting angiogenesis. 4-Methoxycinnamic acid ethyl ester has a significant inhibitory effect on dengue virus and Mycobacterium tuberculosis. 4-Methoxycinnamic acid ethyl ester has analgesic effects in rats.
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Lanatoside C (Standard)
0 ImagesLanatoside C (Standard) is the analytical standard of Lanatoside C. This product is intended for research and analytical applications. Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71.
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Ethyl (S)-2-aminobutanoate (hydrochloride)
0 ImagesCat. No.: HY-W108474CAS No.: 91462-82-7Synonyms: Ethyl (2S)-2-aminobutanoate (hydrochloride); H-Abu-OEt (hydrochloride)Ethyl (S)-2-aminobutanoate hydrochloride (Ethyl (2S)-2-aminobutanoate hydrochloride) is an antiviral compound. Ethyl (S)-2-aminobutanoate hydrochloride exhibits antiviral activity against RSV A2. Ethyl (S)-2-aminobutanoate hydrochloride can be used in research related to respiratory syncytial virus and DENV-2.
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SP187 hydrochloride
0 ImagesCat. No.: HY-108023CAS No.: 1333144-07-2Synonyms: MON-DNJ hydrochloride; UV4 hydrochlorideSP187 hydrochloride (MON-DNJ hydrochloride; UV4 hydrochloride) is an orally active, host-targeting iminosaccharide against filovirus infection. SP187 hydrochloride inhibits endoplasmic reticulum glucosidase. SP187 hydrochloride exhibits antiviral and Dengue Virus activity in vivo. SP187 hydrochloride can be used in antiviral and dengue research.
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CNP0296775
0 ImagesCat. No.: HY-N12612CAS No.: 59204-62-5CNP0296775 is an inhibitor of dengue virus methyltransferase (DENV MTase) that has the potential to disrupt the viral replication process.
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3'-Deoxy-GTP trisodium
0 ImagesCat. No.: HY-134991ASynonyms: 3′-Deoxyguanosine 5′-triphosphate trisodium3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP trisodium inhibits DENV NS5 RdRp (IC50: 0.02 μM).
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Quinine dihydrochloride
0 ImagesQuinine dihydrochloride is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
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Circulin B
0 ImagesCat. No.: HY-182588CAS No.: 20905-50-4Circulin B is a macrocyclic plant cyclopeptide. Circulin B functions as a plant defense peptide and exhibits antibacterial and anti-HIV activities. Circulin B has high binding affinity for the envelope protein of dengue virus, showing potential anti-dengue virus activity. Circulin B can be used in studies related to dengue virus infection, human immunodeficiency virus infection and microbial infection.
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Quinine hydrochloride dihydrate (Standard)
0 ImagesCat. No.: HY-B0433ARCAS No.: 6119-47-7Quinine (hydrochloride dihydrate) (Standard) is the analytical standard of Quinine (hydrochloride dihydrate). This product is intended for research and analytical applications. Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
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(Rac)-Modipafant (Standard)
0 ImagesCat. No.: HY-108908RCAS No.: 122956-68-7Synonyms: UK-74505 (Standard)(Rac)-Modipafant (Standard) is the analytical standard of (Rac)-Modipafant (HY-108908). This product is intended for research and analytical applications. (Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.
