2. Signaling Pathways
  3. Anti-infection
  4. Dengue Virus
  5. Dengue Virus Activator

Dengue Virus Activator

Dengue Virus Activators (2):

Cat. No. Product Name Effect Purity
  • HY-13707
    Tin(IV) mesoporphyrin IX dichloride
    		Activator
    Tin(IV) mesoporphyrin IX dichloride (Stannsoporfin) is an orally active heme oxygenase (HO) inhibitor. Tin(IV) mesoporphyrin IX dichloride increases DENV RNA replication. Tin(IV) mesoporphyrin IX dichloride enhances the bactericidal activity of the SPaO regimen against chronic Mycobacterium tuberculosis (Mtb)-infected mice. Tin(IV) mesoporphyrin IX dichloride exhibits antitumor effects. Tin(IV) mesoporphyrin IX dichloride is being developed to prevent the development of jaundice in infants with hyperbilirubinemia.
  • HY-161844
    Virapinib
    		Activator
    Virapinib is a macropinocytosis inhibitor with antiviral activity. Virapinib exhibits broad-spectrum antiviral activity against SARS-CoV-2, monkeypox virus, tick-borne encephalitis virus, and Ebola pseudotyped vesicular stomatitis virus, and it enhances Dengue Virus infection. Virapinib blocks viral entry by inhibiting macropinocytosis, reduces syncytium formation in SARS-CoV-2-infected cells, and impairs cellular entry of SARS-CoV-2 variants. Virapinib upregulates the expression of genes related to sterol biosynthesis. Virapinib can be used in studies related to COVID-19, monkeypox, tick-borne encephalitis, and Ebola virus infection.