106344-20-1
Chemical Structure
Tin(IV) mesoporphyrin IX dichloride
Synonym(s): Stannsoporfin; SnMP
- CAS No.: 106344-20-1
- Formula:C34H36Cl2N4O4Sn
- Molecular Weight:754.29
InChIKey: LLDZJTIZVZFNCM-UHEVNVKKSA-J
SMILES: [Cl-][Sn+4]123([N-]4C5=C(CCC(O)=O)C(C)=C4C=C(C(CC)=C6C)[N]1=C6C=C(C(CC)=C7C)[N-]2C7=CC8=[N]3C(C(CCC(O)=O)=C8C)=C5)[Cl-]
Biological Activity: Tin(IV) mesoporphyrin IX dichloride (Stannsoporfin) is an orally active heme oxygenase (HO) inhibitor. Tin(IV) mesoporphyrin IX dichloride increases DENV RNA replication. Tin(IV) mesoporphyrin IX dichloride enhances the bactericidal activity of the SPaO regimen against chronic Mycobacterium tuberculosis (Mtb)-infected mice. Tin(IV) mesoporphyrin IX dichloride exhibits antitumor effects. Tin(IV) mesoporphyrin IX dichloride is being developed to prevent the development of jaundice in infants with hyperbilirubinemia[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tin(IV) mesoporphyrin IX dichloride | 95.0% | Tin(IV) mesoporphyrin IX dichloride (Stannsoporfin) is an orally active heme oxygenase (HO) inhibitor. Tin(IV) mesoporphyrin IX dichloride increases DENV RNA replication. Tin(IV) mesoporphyrin IX dichloride enhances the bactericidal activity of the SPaO regimen against chronic Mycobacterium tuberculosis (Mtb)-infected mice. Tin(IV) mesoporphyrin IX dichloride exhibits antitumor effects. Tin(IV) mesoporphyrin IX dichloride is being developed to prevent the development of jaundice in infants with hyperbilirubinemia. | ||||||||||||||||||||
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- [1]. Benjamin Levinson, et al. Treatment of infant hyperbilirubinemia using low dosages of stannsoporfin. US20080113955A1.
- [2]. Lakhani HV, et al. Dysregulation of HO-1-SIRT1 Axis is Associated with AngII-Induced Adipocyte Dysfunction. J Clin Med Sci. 2024;8(2):1000275. Epub 2024 May 20. [Content Brief]
- [3]. Hou C, et al. Inhibition of Heme Oxygenase 1 Suppresses Growth, Migration, and Invasion, and Regulates Tumor-Infiltrating CD8+ T Cells and in Uveal Melanoma. Invest Ophthalmol Vis Sci. 2024 Aug 1;65(10):37. [Content Brief]
- [4]. Sosnowska D, et al. Tumor microenvironments with an active type I IFN response are sensitive to inhibitors of heme degradation. JCI Insight. 2025 Jul 8;10(16):e191017. [Content Brief]
- [5]. Ou YL, et al. Sofalcone Suppresses Dengue Virus Replication by Activating Heme Oxygenase-1-Mediated Antiviral Interferon Responses. Int J Mol Sci. 2025 Jun 20;26(13):5921. [Content Brief]
- [6]. Castillo JR, et al. The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model. bioRxiv [Preprint]. 2023 Nov 13:2023.08.09.552716. [Content Brief]
- [7]. Williams M M, et al. 905 Metastatic triple-negative breast cancer secretes heme metabolites to alter macrophage immune suppression and function. 2024.
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