Tin(IV) mesoporphyrin IX dichloride
Based on 1 Customer Validation
Tin(IV) mesoporphyrin IX dichloride (Stannsoporfin) is an orally active heme oxygenase (HO) inhibitor. Tin(IV) mesoporphyrin IX dichloride increases DENV RNA replication. Tin(IV) mesoporphyrin IX dichloride enhances the bactericidal activity of the SPaO regimen against chronic Mycobacterium tuberculosis (Mtb)-infected mice. Tin(IV) mesoporphyrin IX dichloride exhibits antitumor effects. Tin(IV) mesoporphyrin IX dichloride is being developed to prevent the development of jaundice in infants with hyperbilirubinemia.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 106344-20-1
- Formula: C34H36Cl2N4O4Sn
- Molecular Weight:754.29
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HO[1]
Tin(IV) mesoporphyrin IX dichloride (25 μM; 24 h) does not enhance the inhibitory effect of IFN-β1 on PY8119 cell viability when co-treated with IFN-β1[4].
Tin(IV) mesoporphyrin IX dichloride (1-20 μM; 3 days) reduces the antiviral effect of Sofalcone (HY-B2184) on dengue virus (DENV)-infected Huh-7 cells, reverses the upregulation of HO-1 and interferon (IFN)-related genes[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7
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Concentration:1 μM, 5 μM, 10 μM, 15 μM, 20 μM
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Incubation Time:3 days
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Result:Reversed the Sofalcone-induced upregulation of HO-1 mRNA.
Downregulated IFN-α2, IFN-α17, OAS1, OAS2, and OAS3 mRNA expression.
Increased DENV RNA replication.
Tin(IV) mesoporphyrin IX dichloride (5-10 mg/kg; i.p.; once daily; 4-6 weeks) enhances the bactericidal activity of the SPaO regimen in BALB/c mice with chronic Mycobacterium tuberculosis (Mtb) infection, reduces lung bacterial burden, and does not alter lung pathology[6].
Tin(IV) mesoporphyrin IX dichloride (25 mg/kg; p.o.; daily) decreases bilirubin levels in 66Cl-4 TNBC tumor interstitial fluid in immunocompetent mice, reduces the immunosuppressive ability of tumor-associated macrophages, and does not affect mouse survival[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice (6-8 weeks old, weight 21-26 g) with chronic Mycobacterium tuberculosis (Mtb) H37Rv infection[6]
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Dosage:5 mg/kg, 10 mg/kg
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Administration:Intraperitoneal injection, daily; 4 weeks or 6 weeks
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Result:Resulted in a 0.69 log10 CFU lower lung bacterial load in the SPaO+SnMP (5 mg/kg) group than in the SPaO alone group (after 4 weeks).
Resulted in a 0.78 log10 CFU lower lung bacterial load in the SPaO+SnMP (10 mg/kg) group than in the SPaO alone group (after 6 weeks).
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 106344-20-1
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Appearance Solid
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Molecular Weight 754.29
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Formula C34H36Cl2N4O4Sn
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Color Brown to reddish brown
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SMILES
[Cl-][Sn+4]123([N-]4C5=C(CCC(O)=O)C(C)=C4C=C(C(CC)=C6C)[N]1=C6C=C(C(CC)=C7C)[N-]2C7=CC8=[N]3C(C(CCC(O)=O)=C8C)=C5)[Cl-]
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Synonyms
Stannsoporfin; SnMP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 5.56 mg/mL (7.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.56 mg/mL (0.74 mM); Clear solution
This protocol yields a clear solution of ≥ 0.56 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.6 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (287 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[2]. Lakhani HV, et al. Dysregulation of HO-1-SIRT1 Axis is Associated with AngII-Induced Adipocyte Dysfunction. J Clin Med Sci. 2024;8(2):1000275. Epub 2024 May 20. [Content Brief]
[3]. Hou C, et al. Inhibition of Heme Oxygenase 1 Suppresses Growth, Migration, and Invasion, and Regulates Tumor-Infiltrating CD8+ T Cells and in Uveal Melanoma. Invest Ophthalmol Vis Sci. 2024 Aug 1;65(10):37. [Content Brief]
[4]. Sosnowska D, et al. Tumor microenvironments with an active type I IFN response are sensitive to inhibitors of heme degradation. JCI Insight. 2025 Jul 8;10(16):e191017. [Content Brief]
[5]. Ou YL, et al. Sofalcone Suppresses Dengue Virus Replication by Activating Heme Oxygenase-1-Mediated Antiviral Interferon Responses. Int J Mol Sci. 2025 Jun 20;26(13):5921. [Content Brief]
[6]. Castillo JR, et al. The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model. bioRxiv [Preprint]. 2023 Nov 13:2023.08.09.552716. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3258 mL | 6.6288 mL | 13.2575 mL | 33.1438 mL |
| 5 mM | 0.2652 mL | 1.3258 mL | 2.6515 mL | 6.6288 mL |
Tin(IV) mesoporphyrin IX dichloride Related Classifications
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