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Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Verwandte Produkte (3817):

Art. -Nr. Produktname Wirkung Reinheit Chemical Structure
  • HY-W585827
    2-Chloro-1,3-propanediol
    		99.56%
    2-Chloro-1,3-propanediol is an ester product.
    2-Chloro-1,3-propanediol
  • HY-W741075
    1-Linolenoyl-3-chloropropanediol
    		99.6%
    1-Linolenoyl-3-chloropropanediol is an ester product.
    1-Linolenoyl-3-chloropropanediol
  • HY-W109038
    4-Propylcatechol
    		99.74%
    4-Propylcatechol is an Allylpyrocatechol (HY-124127) analog. 4-Propylcatechol shows anti-malarial activity against Plasmodium falciparum CDC-1 with an IC50 of 32 µM.
    4-Propylcatechol
  • HY-B1149
    Bacampicillin
    Bacampicillin is an orally active semi-synthetic aminopenicillin derivative, prodrug and bactericide that is readily inactivated by β-lactamases. Bacampicillin is hydrolyzed by carboxylester hydrolases and non-specific esterases in the gastrointestinal wall and plasma to form Ampicillin (HY-B0522), and produces higher levels of Ampicillin in rodents in vivo. Bacampicillin exhibits bactericidal activity against Gram-positive and Gram-negative bacteria. Bacampicillin can be used in studies related to bacterial infections.
    Bacampicillin
  • HY-W142855
    Triacontane
    		99.15%
    Triacontane is an ester product.
    Triacontane
  • HY-48239
    WAY-358981
    WAY-358981 is an active molecule.
    WAY-358981
  • HY-176049
    Dasatinib derivative 1
    		99.74%
    Dasatinib derivative 1 (2e) effectively releases NO and increases the concentration of 3′,5′-cyclic guanosine monophosphate, as well as maintains senolytic activity. Dasatinib derivative 1 (2e) can be used in the research for chronic ocular hypertension (COHT) glaucoma.
    Dasatinib derivative 1
  • HY-W364575
    Methyl-4-oxoretinoate
    		98.75%
    Methyl-4-oxoretinoate is a derivative of Retinoic acid (HY-14649). Methyl-4-oxoretinoate inhibits TPA (HY-18739)-induced ornithine decarboxylase (ODC) activity, and carcinogen-induced papillomas in mouse skin.
    Methyl-4-oxoretinoate
  • HY-W140713
    (R)-Methyl 3-hydroxytetradecanoate
    		98.90%
    (R)-Methyl 3-hydroxytetradecanoate is an ester product.
    (R)-Methyl 3-hydroxytetradecanoate
  • HY-N10685
    3,7,25-Trihydroxycucurbita-5,23-dien-19-al
    3,7,25-Trihydroxycucurbita-5,23-dien-19-al (TCD) is a natural product, that can be isolated from the chloroform extract of the leaves of Momordica foetida.
    3,7,25-Trihydroxycucurbita-5,23-dien-19-al
  • HY-185464
    DBCO-Headpiece
    DBCO-Headpiece is a conjugate of DBCO-PEG4-NHS ester (HY-140272) and Headpiece (HY-185129).
    DBCO-Headpiece
  • HY-16514
    Vindesine
    Vindesine is a derivative of Vinblastine (HY-13780). Vindesine binds to and stabilizes tubulin. Vindesine inhibits mitosis in cancer cells and prevents the invasion of normal tissues by malignant cells. Vindesine can be used in cancer research.
    Vindesine
  • HY-160952
    Daunorubicin-Cytarabine Liposome
    Cytarabine-daunorubicin (CPX 351) is a Liposomal formulation prepared from Cytarabine (HY-13605) and Daunorubicin (HY-13062A) at a fixed synergistic molar ratio of 5:1. Cytarabine-daunorubicin improves secondary acute myeloid leukemia. Cytarabine-daunorubicin can be used in research related to secondary acute myeloid leukemia, high-risk myelodysplastic syndrome, and chronic myelomonocytic leukemia.
    Daunorubicin-Cytarabine Liposome
  • HY-16055
    Silatecan
    Silatecan (AR-67) is a blood-brain barrier-permeable derivative of Camptothecin (HY-16560), DNA topoisomerase I inhibitor, an anticancer agent, and a radiosensitizer. Silatecan potently radiosensitizes wild-type p53 gliomas. Silatecan can be used in research related to glioma, leukemia, non-small cell lung cancer, colon cancer, ovarian cancer, renal cancer, prostate cancer, breast cancer, cervical cancer, gastric cancer, nasopharyngeal cancer, and uterine cancer.
    Silatecan
  • HY-121309R
    Doxorubicinone (Standard)
    Doxorubicinone (Adriamycin aglycone) (Standard) is the analytical standard of Doxorubicinone. This product is intended for research and analytical applications. Doxorubicinone is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research.
    Doxorubicinone (Standard)
  • HY-119108
    Emitefur
    Emitefur is an orally active and potent anticancer drug. Emitefur can be used for advanced gastric cancer patients.
    Emitefur
  • HY-144872
    RJ-34
    RJ-34, an aristolactam analogue, exhibits potent antitumor activities against a broad array of cancer cell lines with GI50 values in the subnanomolar range (GI50 <0.1 nM for A431, MES-SA, MES-SA/DX5, HCT-15, and HCT-15/CLO2 cells).
    RJ-34
  • HY-16247
    Apoptone
    Apoptone (HE3235) is an orally active 3β-androstanediol analog. Apoptone reduces the expression of androgen receptor (Androgen receptor) and decreases intratumoral androgen levels. Apoptone exhibits anticancer activity against castration-resistant prostate cancer.
    Apoptone
  • HY-W010062R
    4-Chlorophenylacetic acid (Standard)
    4-Chlorophenylacetic acid (Standard) is the analytical standard of 4-Chlorophenylacetic acid. This product is intended for research and analytical applications. 4-Chlorophenylacetic acid is a halogenated phenylacetic acid derivative. 4-Chlorophenylacetic acid is a potent aromatase inhibitor and antagonizes estrogen signaling. 4-Chlorophenylacetic acid can provide carbon and energy for Pseudomonas sp. strain CBS3. 4-Chlorophenylacetic acid is effective against estrogen-induced mammary tumorigenesis.
    4-Chlorophenylacetic acid (Standard)
  • HY-184265
    Mito-Esculetin
    Mito-Esculetin (Mito-Esc) is an orally active mitochondria-targeted derivative of Esculetin (HY-N0284). Mito-Esculetin inhibits LPS-induced phosphorylation of STAT3 Tyr-705, partially reverses LPS-mediated depletion of SIRT3, and enhances the AMPK-SIRT1 signaling axis. Mito-Esculetin inhibits PAI-1 activity, regulates miRNA, and induces phosphorylation of IRS and AKT. Mito-Esculetin suppresses oxidant-induced endothelial dysfunction, Ang-II (HY-13948)- and high glucose-induced atherosclerotic plaque formation, Palmitate (HY-N0830)-induced insulin resistance, as well as high glucose-mediated endothelial cell senescence and inflammatory responses. Mito-Esculetin reduces body weight and non-esterified fatty acid (NEFA) levels. Mito-Esculetin can be used in research related to acute coronary syndrome, type 2 diabetes, and hyperglycemia-induced atherosclerosis.
    Mito-Esculetin