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  3. Drug Derivative
  4. Dasatinib derivative 1

Dasatinib derivative 1 (2e) effectively releases NO and increases the concentration of 3′,5′-cyclic guanosine monophosphate, as well as maintains senolytic activity. Dasatinib derivative 1 (2e) can be used in the research for chronic ocular hypertension (COHT) glaucoma.

For research use only. We do not sell to patients.

Dasatinib derivative 1

Dasatinib derivative 1 Chemical Structure

CAS No. : 3079237-53-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
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Description

Dasatinib derivative 1 (2e) effectively releases NO and increases the concentration of 3′,5′-cyclic guanosine monophosphate, as well as maintains senolytic activity. Dasatinib derivative 1 (2e) can be used in the research for chronic ocular hypertension (COHT) glaucoma[1].

Molecular Weight

1188.69

Formula

C41H54ClN9O20S5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=[N+](ON=C1OCCOCCOC(CCC(OCCN2CCN(CC2)C3=NC(C)=NC(NC4=NC=C(S4)C(NC5=C(C=CC=C5Cl)C)=O)=C3)=O)=O)[O-])(C6=CC=CC=C6)=O.OS(=O)(C)=O.OS(=O)(C)=O.OS(=O)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (42.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8413 mL 4.2063 mL 8.4126 mL
5 mM 0.1683 mL 0.8413 mL 1.6825 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8413 mL 4.2063 mL 8.4126 mL 21.0316 mL
5 mM 0.1683 mL 0.8413 mL 1.6825 mL 4.2063 mL
10 mM 0.0841 mL 0.4206 mL 0.8413 mL 2.1032 mL
15 mM 0.0561 mL 0.2804 mL 0.5608 mL 1.4021 mL
20 mM 0.0421 mL 0.2103 mL 0.4206 mL 1.0516 mL
25 mM 0.0337 mL 0.1683 mL 0.3365 mL 0.8413 mL
30 mM 0.0280 mL 0.1402 mL 0.2804 mL 0.7011 mL
40 mM 0.0210 mL 0.1052 mL 0.2103 mL 0.5258 mL
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Dasatinib derivative 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dasatinib derivative 13079237-53-6Dasatinib derivative1Dasatinib derivative-1Drug DerivativeDrug derivativeInhibitorinhibitorinhibit

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