2-Chloro-1,3-propanediol
Based on 1 Customer Validation
2-Chloro-1,3-propanediol (2-MCPD) is a pharmaceutical intermediate. 2-Chloro-1,3-propanediol is a common glycerol-derived chemical intermediate and also a food processing contaminant. 2-Chloro-1,3-propanediol can cross the intestinal barrier model via paracellular diffusion. 2-Chloro-1,3-propanediol induces renal and testicular toxicity in animal models. 2-Chloro-1,3-propanediol can be used in research related to organic synthesis.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 497-04-1
- Formula: C3H7ClO2
- Molecular Weight:110.54
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
2-Chloro-1,3-propanediol (2-MCPD) (10 µM-1 mM; 48 h) does not reduce the viability of human colon adenocarcinoma Caco-2 cells[1].
2-Chloro-1,3-propanediol (1-100 µM; 48 h) does not induce caspase 3/7 activity in human colon adenocarcinoma Caco-2 cells at concentrations of 10 µM or 100 µM, but significantly reduces this activity at a concentration of 1 µM[1].
2-Chloro-1,3-propanediol (100 µM; 0-50 h) can freely cross the differentiated human colon adenocarcinoma Caco-2 cell monolayer model via passive diffusion, reaches equilibrium within 12 h, and is not metabolized or absorbed by the cells[1].
2-Chloro-1,3-propanediol exists in both bound and free forms in various non-oil food matrices, and its detection rate and concentration vary by food category; the free form is only detectable in a small number of foods[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human colon adenocarcinoma Caco-2 cells
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Concentration:10 µM, 100 µM, 250 µM, 500 µM, 1 mM
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Incubation Time:48 h
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Result:Showed no cytotoxic effects at all tested concentrations.
Maintained relative cellular viability at ~80-100% compared to untreated control cells, with only minor, non-significant reductions at lower concentrations.
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Cell Line:human colon adenocarcinoma Caco-2 cells
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Concentration:1 µM, 10 µM, 100 µM
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Incubation Time:48 h
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Result:Reduced relative caspase 3/7 activity to ~50% of untreated control levels at 1 µM.
Maintained relative caspase 3/7 activity near control levels (~80-100%) at 10 µM and 100 µM.
Showed no induction of apoptosis-related caspase activity at 10 µM or 100 µM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 497-04-1
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Appearance Liquid (Density: 1.3219 g/cm3)
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Molecular Weight 110.54
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Formula C3H7ClO2
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Color Colorless to light yellow
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SMILES
OCC(Cl)CO
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Synonyms
2-MCPD
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (904.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Buhrke T, et al. 2-Chloro-1,3-propanediol (2-MCPD) and its fatty acid esters: cytotoxicity, metabolism, and transport by human intestinal Caco-2 cells. Archives of toxicology. 2015 Dec;89(12):2243-51. [Content Brief]
[2]. Ozluk G, et al. Chloropropanols and Their Esters in Food: An Updated Review. Foods (Basel, Switzerland). 2024 Sep 11;13(18):2876. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 9.0465 mL | 45.2325 mL | 90.4650 mL | 226.1625 mL |
| 5 mM | 1.8093 mL | 9.0465 mL | 18.0930 mL | 45.2325 mL | |
| 10 mM | 0.9046 mL | 4.5232 mL | 9.0465 mL | 22.6162 mL | |
| 15 mM | 0.6031 mL | 3.0155 mL | 6.0310 mL | 15.0775 mL | |
| 20 mM | 0.4523 mL | 2.2616 mL | 4.5232 mL | 11.3081 mL | |
| 25 mM | 0.3619 mL | 1.8093 mL | 3.6186 mL | 9.0465 mL | |
| 30 mM | 0.3015 mL | 1.5077 mL | 3.0155 mL | 7.5387 mL | |
| 40 mM | 0.2262 mL | 1.1308 mL | 2.2616 mL | 5.6541 mL | |
| 50 mM | 0.1809 mL | 0.9046 mL | 1.8093 mL | 4.5232 mL | |
| 60 mM | 0.1508 mL | 0.7539 mL | 1.5077 mL | 3.7694 mL | |
| 80 mM | 0.1131 mL | 0.5654 mL | 1.1308 mL | 2.8270 mL | |
| 100 mM | 0.0905 mL | 0.4523 mL | 0.9046 mL | 2.2616 mL |
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