RJ-34
RJ-34, an aristolactam analogue, exhibits potent antitumor activities against a broad array of cancer cell lines with GI50 values in the subnanomolar range (GI50 <0.1 nM for A431, MES-SA, MES-SA/DX5, HCT-15, and HCT-15/CLO2 cells).
For research use only. We do not sell to patients.
- CAS No.: 1170694-29-7
- Formula: C22H22N2O5
- Molecular Weight:394.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | GI50 |
<0.0001 μM
Compound: 34
|
Antiproliferative activity against human A431 cells by SRB assay
Antiproliferative activity against human A431 cells by SRB assay
|
[PMID: 19394218] |
| A-431 | GI50 |
<0.1 nM
Compound: 34
|
Antiproliferative activity against human A431 cells by SRB assay
Antiproliferative activity against human A431 cells by SRB assay
|
[PMID: 19394218] |
| A549 | GI50 |
<0.1 μM
Compound: 34
|
Antiproliferative activity against human A549 cells by SRB assay
Antiproliferative activity against human A549 cells by SRB assay
|
[PMID: 19394218] |
| HCT-15 | GI50 |
0.0095 μM
Compound: 34
|
Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay
Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay
|
[PMID: 19394218] |
| HCT-15 | GI50 |
<0.0001 μM
Compound: 34
|
Antiproliferative activity against human HCT15 cells by SRB assay
Antiproliferative activity against human HCT15 cells by SRB assay
|
[PMID: 19394218] |
| HCT-15 | GI50 |
<0.1 nM
Compound: 34
|
Antiproliferative activity against human HCT15 cells by SRB assay
Antiproliferative activity against human HCT15 cells by SRB assay
|
[PMID: 19394218] |
| MES-SA | GI50 |
<0.0001 μM
Compound: 34
|
Antiproliferative activity against human MESSA cells by SRB assay
Antiproliferative activity against human MESSA cells by SRB assay
|
[PMID: 19394218] |
| MES-SA | GI50 |
<0.1 nM
Compound: 34
|
Antiproliferative activity against human MESSA cells by SRB assay
Antiproliferative activity against human MESSA cells by SRB assay
|
[PMID: 19394218] |
| MES-SA/Dx5 | GI50 |
<0.0001 μM
Compound: 34
|
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
|
[PMID: 19394218] |
| MES-SA/Dx5 | GI50 |
<0.1 nM
Compound: 34
|
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
|
[PMID: 19394218] |
| SK-OV-3 | GI50 |
<0.1 μM
Compound: 34
|
Antiproliferative activity against human SKOV3 cells by SRB assay
Antiproliferative activity against human SKOV3 cells by SRB assay
|
[PMID: 19394218] |
Chemical Information
-
CAS No. 1170694-29-7
-
Molecular Weight 394.42
-
Formula C22H22N2O5
-
SMILES
O=C1N(CCN(C)C)C2=C3C1=CC(OC)=C(OC)C3=C(C=C4)C(C5=C4OCO5)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)