GCGR

Glucagon Receptor

GCGR

Related Products

GCGR (glucagon receptor) is in the G protein-coupled receptor family, that is important in controlling blood glucose levels. The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene. Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.

GCGR Related Products (190)
Recombinant Proteins (14)
Antibodies (3)

By Effects:	Inhibitors (12) Agonists (90) Controls (4) Antagonists (40) Activator (1) Modulators (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P5161

FC382K10W15	Agonist
FC382K10W15 is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 can be used in type 2 diabetes research.

HY-P5578

A8SGLP-1	Agonist
A8SGLP-1 is an orally active GLP-1 analogue that the alanine at position 8 substituted with serine. A8SGLP-1 reduces blood glucose in db/db mice without affecting its function.

HY-P11044

GEP12	Agonist
GEP12 is a GLP-1R/Y1-R/Y2-R tri-receptor agonist peptide with an EC₅₀ of 17.3 nM and an IC₅₀ of 19.2 nM for receptor binding. GEP12 may promote glycemic control and weight loss.

HY-P0212A

Neuropeptide Y, porcine TFA
Neuropeptide Y, porcine TFA, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion.

HY-144135

GLP-1R agonist 7	Agonist
GLP-1R agonist 7 is a potent GLP-1R agonist with an EC₅₀ of 0.67 µM (WO2021244645A1, compound WXA001).

HY-P3542

Des His1, Glu8 Exendin-4	Antagonist
Des His1, Glu8 Exendin-4 is a potent glucagon-like peptide-1 receptor (GLP-1-R) antagonist. Des His1, Glu8 Exendin-4 improves glucose homeostasis by regulating both insulin secretion and glucose production. Des His1, Glu8 Exendin-4 can be used for the research of type 2 diabetic and gastrointestinal.

HY-P5161A

FC382K10W15 TFA	Agonist
FC382K10W15 TFA is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 TFA can be used in type 2 diabetes research.

HY-P3539

Exendin-4 (3-39)
Exendin-4 (3-39) is a peptide. Exendin-4 (3-39) is a truncated form of Exendin-4 (HY-13443) that lacks the first two amino acids. Exendin-4 is a potent Glucagon-like peptide-1 receptor (GLP-1r) agonist. Exendin-4 (3-39) and Exendin-4 can be used for the research of diabetic and hypothalamic-pituitary-adrenal (HPA) axis.

HY-P4503

(D-His1)-Exenatide	Control
(D-His1)-Exenatide is one od impurities of Exenatide.

HY-120401

Glybuzole	Activator
Glybuzole (Desaglybuzole) is an orally active hypoglycaemic agent that has antidiabetic effect.

HY-144134

GLP-1R agonist 6	Agonist
GLP-1R agonist 6 is a potent GLP-1R agonist with an EC₅₀ of 0.15 nM for human GLP-1R (WO2021249492A1, compound 005A or 005B).

HY-107129

MK-3577	Antagonist
MK-3577 is an orally effective glucagon receptor (GCGR) antagonist that reduces hepatic glucose production and lowers blood glucose levels by blocking glucagon receptors on target organs, primarily the liver. Pharmacokinetic analysis in domestic cats indicates that MK-3577 reaches peak levels 3 to 4 hours after oral administration, with a half-life of approximately 15 hours. MK-3577 can be used in diabetes research.

HY-P2625S1

GLP-2(3-33) (Leu-¹³C₆,¹⁵NN) TFA	Agonist
GLP-2(3-33) (Leu-¹³C₆,¹⁵N) TFA is ¹³C and ¹⁵N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC₅₀=5.8 nM).

HY-159696

ISIS 449884	Inhibitor
ISIS 449884 is a 2'-O-methoxyethyl antisense oligonucleotide that targets GCGR. ISIS 449884 has an ability to reduce hepatic glucose output and lower the blood glucose level. ISIS 449884 can be used for the study of type 2 diabetes mellitus (T2DM).

HY-13443S

Exendin-4 (Leu-¹³C₆,¹⁵N) TFA
Exendin-4 (Leu-¹³C₆,¹⁵N) (Exenatide (Leu-¹³C₆,¹⁵N)) TFA is the ¹³C- and ¹⁵N-labeled Exendin-4 TFA (HY-13443). Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC₅₀ of 3.22 nM.

HY-P3616

Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide
Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide is a biotin labeled glucagon-like peptide-1-(7-36). Glucagon-like peptide-1-(7-36) is a gastrointestinal peptide with antidiabetogenic activity, and can increase the release of insulin.

HY-106559

Sorbinicate	Inhibitor
Sorbinicate, a derivative of nicotinic acid, exerts a favourable influence on blood rheology and platelet function.

HY-P2880

PHI-27 (porcine)
PHI-27 (porcine) is a 27 amino acid peptide.PHI-27 (porcine) is used to find peptide hormones and other active peptides.

HY-129656

GLP-1 receptor agonist 3	Agonist
GLP-1 receptor agonist 3 (compound (R)-4A-1) is a GLP-1 receptor agonist (WO2018109607A1), used for diabetes research. compound (S)-4A-1 shows EC₅₀s of 1.1 nM and 13 nM in Clone H6 and Clone C6 cell lines assay, respectively.

HY-P11275

TC4	Agonist
TC4 is a highly balanced single-molecule quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC₅₀ values of 0.95, 31, 81, and 1100 nM respectively. TC4 exhibits extremely strong signal bias on GLP-1R and has very low recruitment efficacy for β-inhibitor protein 2 (βArr2) and this strong cAMP preference is believed to maximize metabolic benefits (such as weight loss and hypoglycemia) while possibly minimizing side effects mediated by β-inhibitor protein recruitment (such as receptor desensitization). TC4 can be used for research on obesity and diabetes.

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GCGR

GCGR

GCGR Related Products (190)

Recombinant Proteins (14)

Antibodies (3)

GCGR Related Products (190):