GCGR Activator
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Steviol glucuronide-13C,d2
0 ImagesCat. No.: HY-W769507Steviol glucuronide-13C,d2 is the 13C,d2-labeled Steviol glucuronide (HY-188367). Steviol glucuronide is a metabolite of Steviol (HY-N2057). Steviol glucuronide upregulates Glucagon receptor transcription and downregulates β-2-microglobulin transcription. Steviol glucuronide scavenges hydroxyl/superoxide radicals and reduces thiobarbituric acid reactive substances, without DPPH/nitric oxide scavenging activity. Steviol glucuronide stimulates glucose-dependent insulin secretion and does not affect basal insulin under low-glucose conditions. Steviol glucuronide enters cells via passive diffusion and OAT3/OATP1B1/OATP1B3/OATP2B1-mediated uptake, and inhibits OATP1B1/OATP1B3-mediated transport of Rosuvastatin (HY-17504B). Steviol glucuronide can be used in research on type 2 diabetes.
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Glybuzole
0 ImagesGlybuzole (Desaglybuzole) is an orally effective hypoglycemic agent. Glybuzole promotes insulin secretion by pancreatic β cells and inhibits glucagon secretion by pancreatic α cells. Glybuzole reduces blood glucose levels as well as arginine-stimulated plasma glucagon levels. Glybuzole can be used in diabetes-related research.
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GLP-1R modulator-2
0 ImagesCat. No.: HY-188129CAS No.: 2889348-10-9GLP-1R modulator-2 is a GLP-1R positive allosteric modulator with an EC50 of 106 nM. GLP-1R modulator-2 simultaneously binds to the extracellular pocket of GLP-1R and the peptide ligand GLP-1 (9-36) through a molecular glue-like allosteric effect, and selectively enhances GLP-1 (9-36)-induced G protein-dependent cAMP signaling. When used in combination with GLP-1 (9-36) under high-glucose conditions, GLP-1R modulator-2 enhances glucose-dependent insulin secretion in wild-type rat pancreatic islets. GLP-1R modulator-2 exhibits strong probe dependence and significantly potentiates the activity of GLP-1 (9-36). GLP-1R modulator-2 can be used for research on type 2 diabetes and obesity .
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Steviol glucuronide
0 ImagesCat. No.: HY-188367CAS No.: 885044-59-7Steviol glucuronide is a metabolite of Steviol (HY-N2057). Steviol glucuronide upregulates Glucagon receptor transcription and downregulates β-2-microglobulin transcription. Steviol glucuronide scavenges hydroxyl/superoxide radicals and reduces thiobarbituric acid reactive substances, without DPPH/nitric oxide scavenging activity. Steviol glucuronide stimulates glucose-dependent insulin secretion and does not affect basal insulin under low-glucose conditions. Steviol glucuronide enters cells via passive diffusion and OAT3/OATP1B1/OATP1B3/OATP2B1-mediated uptake, and inhibits OATP1B1/OATP1B3-mediated transport of Rosuvastatin (HY-17504B). Steviol glucuronide can be used in research on type 2 diabetes.
