1492-02-0
Chemical Structure
Glybuzole
Synonym(s): Desaglybuzole
- CAS No.: 1492-02-0
- Formula:C12H15N3O2S2
- Molecular Weight:297.40
IUPAC Name: N-(5-(tert-butyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide
InChIKey: NMWQEPCLNXHPDX-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC=C1)(NC2=NN=C(C(C)(C)C)S2)=O
Biological Activity: Glybuzole (Desaglybuzole) is an orally effective hypoglycemic agent. Glybuzole promotes insulin secretion by pancreatic β cells and inhibits glucagon secretion by pancreatic α cells. Glybuzole reduces blood glucose levels as well as arginine-stimulated plasma glucagon levels. Glybuzole can be used in diabetes-related research[1][2][3].
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Glybuzole | Glybuzole (Desaglybuzole) is an orally effective hypoglycemic agent. Glybuzole promotes insulin secretion by pancreatic β cells and inhibits glucagon secretion by pancreatic α cells. Glybuzole reduces blood glucose levels as well as arginine-stimulated plasma glucagon levels. Glybuzole can be used in diabetes-related research. | |||||||||||||||||||||
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[1]. 石井正二, et al. (1975). Glybuzole の膵 α 細胞機能に及ぼす影響に関する実験的および臨床的研究. 糖尿病, 18(2), 149-155.
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[2]. 石井昭男, 大石孝義, 遠藤守俊, & 峯浦和幸. (1978). Glybuzole (2-Benzenesulfonamido-5-tert-butyl-1-thia-3, 4-diazole) のフエノバルビタール, SKF 525A および四塩化炭素前処理ラットにおける代謝. YAKUGAKU ZASSHI, 98(9), 1208-1214.
- [3]. Otsuka M, Ofusa T, Matsuda Y. Physicochemical characterization of glybuzole polymorphs and their pharmaceutical properties. Drug development and industrial pharmacy. 1999 Feb;25(2):197-203. [Content Brief]
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